Towards Greener and More Efficient C-C and C-Heteroatom Couplings: Present and Future

Author(s): Carolina Vargas, Alina Mariana Balu, Juan Manuel Campelo, Camino Gonzalez-Arellano, Rafael Luque, Antonio Angel Romero.

Journal Name: Current Organic Synthesis

Volume 7 , Issue 6 , 2010

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C-C and C-Heteroatom couplings are among the most relevant processes in Organic Synthesis. These reactions can provide access to a wide range of carbon-carbon and carbon-heteroatom scaffolds that find applications in many different areas including agriculture, pharmacy, medicine, cosmetics and natural products. Current societys driving force towards more efficient methodologies (with improved environmental compatibilities at the same time) to meet the requirements of a more sustainable chemical industry, has created the need to search for alternative methodologies to traditionally wasteful and energy intensive protocols that also involve rather complex reaction conditions and media as well as homogeneous transition metal catalysts. In this contribution, we aim to provide an overview of the present and future of greener C-C and C-Heteroatom protocols with selected examples to highlight the latest trends in this field.

Keywords: C-C couplings, C-Heteroatom couplings, Green Chemistry, organic synthesis, heterogeneous catalysis, microwaves

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Article Details

Year: 2010
Page: [568 - 586]
Pages: 19
DOI: 10.2174/157017910794328547
Price: $58

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