Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Pharmacological Activity of Thiourea Derivatives of 1,7,8,9-Tetramethyl-4-azatricyclo[,6]dec-8-ene-3,5-dione

Author(s): Marta Struga, Jerzy Kossakowski, Anna E. Koziol, Tateusz Lis, Ewa Kedzierska, Sylwia Fidecka.


A series of new thiourea derivatives of 1,7,8,9-tetramethyl-4-azatricyclo[,6]dec-8-ene-3,5-dione have been prepared. The compound 6 was tested for pharmacological activity on animal central nervous system (CNS). The data suggest that compound 6 significantly interacts with 5-HT2 receptors in the brain. The activities of synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells. Elementary analysis, MS, 1H NMR spectra confirmed the identity of the products. The molecular structure of 12 was determined by an X-ray analysis.

Keywords: Thiourea derivatives, Pharmacological activity, X-ray analysis

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Article Details

Year: 2009
Page: [445 - 450]
Pages: 6
DOI: 10.2174/157018009789057517
Price: $58