Microwave-Assisted Synthesis of Imido-Substituted 2-Chloro-1,4-naphthoquinone Derivatives and their Cytotoxic Activities on Three Human Prostate Cancer Cell Lines
Solomon Berhe, Yasmine Kanaan, Robert L. Copeland Jr., Dwayne A. Wright, Leon H. Zalkow and Oladapo Bakare
Affiliation: Department of Chemistry, Howard University, Washington DC 20059, USA.
The anticancer activities of six imido-substituted 2-chloro-1,4-naphthoquinone derivatives on one androgendependent, LNCaP, and two androgen-independent, PC3 and DU145, human prostate cancer cell lines are reported. The open chain imides (2-4) showed more potency in all three cell lines. In addition the microwave-assisted synthesis of five of these compounds is reported.
Keywords: Prostate cancer, 2-Chloro-1, 4-naphthoquinone, Imides, Microwave-assisted synthesis
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