Microwave-Assisted Synthesis of Imido-Substituted 2-Chloro-1,4-naphthoquinone Derivatives and their Cytotoxic Activities on Three Human Prostate Cancer Cell Lines
Robert L. Copeland Jr.,
Dwayne A. Wright,
Leon H. Zalkow,
The anticancer activities of six imido-substituted 2-chloro-1,4-naphthoquinone derivatives on one androgendependent, LNCaP, and two androgen-independent, PC3 and DU145, human prostate cancer cell lines are reported. The open chain imides (2-4) showed more potency in all three cell lines. In addition the microwave-assisted synthesis of five of these compounds is reported.
Keywords: Prostate cancer, 2-Chloro-1, 4-naphthoquinone, Imides, Microwave-assisted synthesis
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