Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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Tamarind Inhibits Solar-Simulated Ultraviolet Radiation-Induced Suppression of Recall Responses in Humans

Author(s): J. M. Kuchel, R. St. C. Barnetson, L. Zhuang, F. M. Strickland, R. P. Pelley and G. M. Halliday

Affiliation: Dermatology Laboratories, Blackburn Building, D06, University of Sydney, Sydney, N.S.W.,Australia, 2006.

Abstract:

To determine whether topically applied biologically active drugs can be used to protect the human immune system from sunlight, we studied the effect of tamarind xyloglucan polysaccharide, a natural and common fruit constituent, on solar-simulated, ultraviolet radiation-induced local immunosuppression and erythema in humans. Immunosuppression was studied in humans using a nickel contact hypersensitivity recall model. Ultraviolet dose responses were generated to determine the extent to which tamarind affected the immune response in a group of 15 volunteers. The subsequent nickel-induced erythema was quantitated using a reflectance spectrometer. 0.1 μgml-1 of topical tamarind polysaccharide reduced ultraviolet radiation-induced immunosuppression. Frozen sections of biopsies taken were analysed by immunohistochemistry. Tamarind inhibited ultraviolet radiation-induced CD11c+ dendritic cell loss from the epidermis. The ultraviolet doses used in this study did not alter the number of Mac387+ macrophages or NP57+ neutrophils infiltrating the skin. Low dose xyloglucan polysaccharide from tamarind protected from immunosuppression in humans, possibly by reducing ultraviolet radiation-induced loss of dendritic cells, demonstrating that these types of drugs may be useful adjuncts to sunscreens for protection from skin cancer.

Keywords: tolerance, skin, dendritic cells, tumour immunity, ultraviolet, sunlight

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Article Details

VOLUME: 2
ISSUE: 2
Page: [165 - 171]
Pages: 7
DOI: 10.2174/1570180053175106
Price: $58