Abstract
Ethanol (alcohol) consumption can modify immune responses. Moderate ethanol use is associated with lower production of mediators of inflammation and has anti-inflammatory effect, while ethanol abuse and alcoholism are linked with augmentation of inflammatory responses. Ethanol exposure can result in functional alterations of macrophages and other cells of the innate immune system. These cells recognize microbial antigens through Toll-like receptors (TLRs). Molecular mechanisms underlying the inflammatory responses stimulated via TLRs involve activation of intracellular signaling pathways that include mitogen-activated protein kinases (MAPKs) and transcription factor NFκB. Growing evidence indicates that ethanol can affect these cellular events in a manner that depends on the organ or cell type and the pattern of ethanol administration (moderate or acute versus chronic).
Keywords: Ethanol, inflammation, cardiovascular disease, cytokines, toll-like receptors, MAPK
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Ethanol and Inflammation
Volume: 6 Issue: 4
Author(s): Joanna Goral
Affiliation:
Keywords: Ethanol, inflammation, cardiovascular disease, cytokines, toll-like receptors, MAPK
Abstract: Ethanol (alcohol) consumption can modify immune responses. Moderate ethanol use is associated with lower production of mediators of inflammation and has anti-inflammatory effect, while ethanol abuse and alcoholism are linked with augmentation of inflammatory responses. Ethanol exposure can result in functional alterations of macrophages and other cells of the innate immune system. These cells recognize microbial antigens through Toll-like receptors (TLRs). Molecular mechanisms underlying the inflammatory responses stimulated via TLRs involve activation of intracellular signaling pathways that include mitogen-activated protein kinases (MAPKs) and transcription factor NFκB. Growing evidence indicates that ethanol can affect these cellular events in a manner that depends on the organ or cell type and the pattern of ethanol administration (moderate or acute versus chronic).
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Cite this article as:
Goral Joanna, Ethanol and Inflammation, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2007; 6 (4) . https://dx.doi.org/10.2174/187152307783219970
DOI https://dx.doi.org/10.2174/187152307783219970 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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