Abstract
Type 2 diabetes carries a 2-6-fold increased risk of cardiovascular disease (CVD) and death. Indeed, the risk of major cardiovascular events in Type 2 diabetic patients without history of coronary heart disease (CHD) is equivalent to that observed in non-diabetic subjects with CHD. However, atherosclerosis may also precede the development of diabetes, suggesting that both disorders share common genetic and environmental antecedent factors (“common soil” hypothesis). One such a possible ancestor is insulin resistance which constitutes both a major feature of Type 2 diabetes and an independent risk factor for CHD. It is well documented that inflammatory processes play an important role in the causation of atherosclerotic CVD. Inflammatory mediators play a paramount role in the initiation, progression, and rupture of atherosclerotic plaques. Thus, markers of
Keywords: atherosclerosis, inflammation, macrophages, high sensitivity c-reactive protein (hscrp), low-density lipoprotein (ldl) cholesterol, leukocyte, chemoattraction, interferon, angistensin, crp-transgenic (crp-tg) mouse model
Current Molecular Medicine
Title: Type 2 Diabetes As An Inflammatory Cardiovascular Disorder
Volume: 5 Issue: 3
Author(s): D. Ziegler
Affiliation:
Keywords: atherosclerosis, inflammation, macrophages, high sensitivity c-reactive protein (hscrp), low-density lipoprotein (ldl) cholesterol, leukocyte, chemoattraction, interferon, angistensin, crp-transgenic (crp-tg) mouse model
Abstract: Type 2 diabetes carries a 2-6-fold increased risk of cardiovascular disease (CVD) and death. Indeed, the risk of major cardiovascular events in Type 2 diabetic patients without history of coronary heart disease (CHD) is equivalent to that observed in non-diabetic subjects with CHD. However, atherosclerosis may also precede the development of diabetes, suggesting that both disorders share common genetic and environmental antecedent factors (“common soil” hypothesis). One such a possible ancestor is insulin resistance which constitutes both a major feature of Type 2 diabetes and an independent risk factor for CHD. It is well documented that inflammatory processes play an important role in the causation of atherosclerotic CVD. Inflammatory mediators play a paramount role in the initiation, progression, and rupture of atherosclerotic plaques. Thus, markers of
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Cite this article as:
Ziegler D., Type 2 Diabetes As An Inflammatory Cardiovascular Disorder, Current Molecular Medicine 2005; 5 (3) . https://dx.doi.org/10.2174/1566524053766095
DOI https://dx.doi.org/10.2174/1566524053766095 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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