Abstract
In the last years DNA triplexes have been the subject of a very intense research effort, which has been summarized in a vast number of books and reviews (see for example refs. [1-16]). After a general introduction to DNA polymorphism and the structure of triple helices, we will examine here general approaches to the stabilization of triple helices. Methods based in external binding to DNA and backbone modification will be briefly summarized, and the reader will be addressed to more specific reviews. Finally, we will survey strategies for triplex stabilization based on modification of nucleobases, paying particular attention to recent advances in the field.
Keywords: Nucleic Acid, Triple Helices, Nucleobase Modifications, Pyrimidine
Current Organic Chemistry
Title: Nucleic Acid Triple Helices: Stability Effects of Nucleobase Modifications
Volume: 6 Issue: 14
Author(s): Jordi Robles, Anna Grandas, Enrique Pedroso, F. Javier Luque, Ramon Eritja and Modesto Orozco
Affiliation:
Keywords: Nucleic Acid, Triple Helices, Nucleobase Modifications, Pyrimidine
Abstract: In the last years DNA triplexes have been the subject of a very intense research effort, which has been summarized in a vast number of books and reviews (see for example refs. [1-16]). After a general introduction to DNA polymorphism and the structure of triple helices, we will examine here general approaches to the stabilization of triple helices. Methods based in external binding to DNA and backbone modification will be briefly summarized, and the reader will be addressed to more specific reviews. Finally, we will survey strategies for triplex stabilization based on modification of nucleobases, paying particular attention to recent advances in the field.
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Cite this article as:
Robles Jordi, Grandas Anna, Pedroso Enrique, Luque Javier F., Eritja Ramon and Orozco Modesto, Nucleic Acid Triple Helices: Stability Effects of Nucleobase Modifications, Current Organic Chemistry 2002; 6 (14) . https://dx.doi.org/10.2174/1385272023373482
DOI https://dx.doi.org/10.2174/1385272023373482 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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