Abstract
Marine sponges are shown to be abundant sources of bioactive peptides. Structurally they include linear peptides, peptide lactones, cyclic peptides, and depsipeptides, with number of residues ranging from two to 48. Some of them have highly modified structural features with nonproteinogenic amino acid or hydroxy acid residues, while others have those with minimal alterations from the common ribosomal peptides. The structural characteristics, biogenesis, biological activity, and the issue of producing symbiotic organisms of nonribosomal peptides reported since 1993 are described in the order of structural types.
Keywords: nonribosomal peptides, marine sponges, bioactive peptides, peptide lactones, depsipeptides, nonproteinogenic amino acid, ribosomal peptides
Current Organic Chemistry
Title: Nonribosomal Peptides from Marine Sponges
Volume: 7 Issue: 10
Author(s): Shigeki Matsunaga and Nobuhiro Fusetani
Affiliation:
Keywords: nonribosomal peptides, marine sponges, bioactive peptides, peptide lactones, depsipeptides, nonproteinogenic amino acid, ribosomal peptides
Abstract: Marine sponges are shown to be abundant sources of bioactive peptides. Structurally they include linear peptides, peptide lactones, cyclic peptides, and depsipeptides, with number of residues ranging from two to 48. Some of them have highly modified structural features with nonproteinogenic amino acid or hydroxy acid residues, while others have those with minimal alterations from the common ribosomal peptides. The structural characteristics, biogenesis, biological activity, and the issue of producing symbiotic organisms of nonribosomal peptides reported since 1993 are described in the order of structural types.
Export Options
About this article
Cite this article as:
Matsunaga Shigeki and Fusetani Nobuhiro, Nonribosomal Peptides from Marine Sponges, Current Organic Chemistry 2003; 7 (10) . https://dx.doi.org/10.2174/1385272033486648
DOI https://dx.doi.org/10.2174/1385272033486648 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Chemistry and Biology of Cyperus scariosus: An Overview
Current Chemical Biology Apoptosis-Inducing Activity of the S100A8/A9 Heterodimer
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Genetic Polymorphism of Organic Anion and Cation Transporters: Pharmacokinetic and Pharmacodynamic Consequences in Pharmacotherapy
Current Pharmacogenomics C/EBPα Regulates FOXC1 to Modulate Tumor Growth by Interacting with PPARγ in Hepatocellular Carcinoma
Current Cancer Drug Targets Editorial (Thematic Issue: Drug Reprofiling: An Alternative Path to Drug Discovery)
Current Topics in Medicinal Chemistry Analytical Techniques for Determining Pharmaceutical Residues in Drinking Water – State of Art and Future Prospects
Current Analytical Chemistry Smoking and Eye Pathologies. A Systemic Review. Part I. Anterior Eye Segment Pathologies
Current Pharmaceutical Design Immunotherapy in Gastric Carcinoma: Current Status and Future Perspectives
Clinical Cancer Drugs Psychosocial Stress, Emotions and Cytokine-Related Disorders
Recent Patents on Inflammation & Allergy Drug Discovery The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases
Current Molecular Pharmacology Regulation of TGF-β Signaling by SMADs and its Roles in Tissue Fibrosis
Current Signal Transduction Therapy Novel Therapeutics in Breast Cancer
Current Medicinal Chemistry New Perspectives in the Treatment of Cushings Syndrome
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Hemoglobin Enhances the Biological Activity of Synthetic and Natural Bacterial (Endotoxic) Virulence Factors: A General Principle
Medicinal Chemistry L-Type Voltage-Dependent Calcium Channels As Therapeutic Targets for Neurodegenerative Diseases
Current Medicinal Chemistry Druggability of Dynamic Protein-protein Interfaces
Current Pharmaceutical Design An Overview of Compounds Derived from the Shikimate and Phenylpropanoid Pathways and Their Medicinal Importance
Mini-Reviews in Medicinal Chemistry Free Radicals and Antioxidants: How to Reestablish Redox Homeostasis in Chronic Diseases?
Current Medicinal Chemistry Induction of Serine Racemase Expression and D-Serine Release from Microglia by Secreted Amyloid Precursor Protein (sAPP)
Current Alzheimer Research Physiopathological Roles of P2X Receptors in the Central Nervous System
Current Medicinal Chemistry