Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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Targeting Apoptosis Pathways in Cancer Therapy

Author(s): Simone Fulda, Klaus-Michael Debatin.

Abstract:

Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, e.g. chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly mediated by triggering apoptosis, the cells intrinsic death program. Accordingly, defects in apoptosis pathways can result in cancer resistance to current treatment approaches. Understanding the molecular mechanisms that regulate cell death programs including apoptosis, and how resistant forms of cancer evade apoptotic events, may provide novel opportunities for cancer drug development.

Keywords: apoptosis, cancer, mitochondria, cancer therapy, resistance

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Article Details

VOLUME: 4
ISSUE: 7
Year: 2004
Page: [569 - 576]
Pages: 8
DOI: 10.2174/1568009043332763
Price: $58