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Current Cancer Drug Targets

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Volume 22, Issue 11, 2022

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Editorial Board


ccdt Editor-in-Chief Zhang Ruiwen Center for Drug Discovery University of Houston Houston, TX USA

Ruiwen Zhang is the Robert L. Boblitt Endowed Professor in Drug Discovery and Director of the Drug Discovery Institute at the University of Houston. With over 30 years of experience in the field of biomedical research, particularly in the area of clinical pharmacology and therapeutics, pharmaceutical and toxicological research, Dr. Zhang’s research has been continuously funded by NIH and DoD, and other agencies. He has published more than 230 papers, 2 books, and more than 50 invited reviews/book chapters as well as more than 180 meeting abstracts. For his outstanding contributions in pharmaceutical sciences, Dr. Zhang was elected as a Fellow of American Association for the Advancement of Science (AAAS) in 2009. Dr. Zhang is recently elected as Fellow of National Academy of Inventors (2018).

rwzhang35294@yahoo.com
Co-Editors ccdt_ebm_Yamaguchi-sh_001 Yamaguchi Masayoshi Cancer Biology Program University of Hawai‘i Cancer Center Honolulu HI USA

Dr. Yamaguchi graduated from Shizuoka College of Pharmacy (B.S.) in 1971 and obtained Ph.D of Pharmaceutical Sciences in 1976. He was engaged as Research Associate and Assistant Professor in Shizuoka College of Pharmacy (1973-1987), Assistant Professor in the School of Pharmaceutical Sciences, University of Shizuoka (1987-1991), Associated Professor at the University of Shizuoka, Graduate School of Nutritional Sciences (1991-1993) and Professor at the University of Shizuoka, Graduate School of Nutritional Sciences (1993 ~ 2007) in Japan. From 2007, Yamaguchi was invited as a Visiting Professor, Emory University School of Medicine, Department of Medicine. He was appointed as editorial board member of a number of journals including International Journal of Molecular Medicine, Molecular Medicine Reports, Journal of Osteoporosis, International Journal of Medicine and Medical Sciences, International Journal of Nutrition and Metabolism, Molecular and Cellular Biochemistry, Endocrinology Studies, Alternative Medicine Studies, Experimental and Therapeutic Medicine, and Stem Cell Discovery. Yamaguchi published over 500 English original papers, review articles and books. Dr. Yamaguchi's research fields include the bone and calcium endocrinology and metabolism, nutritional prevention of osteoporosis, and the exploration of intracellular signaling mechanism. Yamaguchi found the novel protein and genes which were named as Regucalcin and RGPR-p117.

yamamasa11555@yahoo.co.jp MYamaguchi@cc.hawai.edu
Associate Editors ccdt_ebm_agarwal-sh_001 Agarwal Rajesh Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Denver Aurora CA USA

Dr. Rajesh Agarwal is a Professor and Vice Chairman of Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of Colorado, USA. His research interests lie in Cancer Pharmacology: chemoprevention of cancer by natural and synthetic agents; Cancer models: skin prostate, breast, lung, colon, bladder, pancreas, and head & neck; Cancer Biology: Oncogenes and tumor suppressor genes, cell cycle and apoptosis modulation, mitogenic and anti-apoptotic signaling, EMT, cancer stem cells, cancer cell metabolism and Warfare vesicants: Cutaneous and ocular injuries by vesicants, and rescue by natural and synthetic agents.

Rajesh.Agarwal@ucdenver.edu Rajesh.Agarwal@UCHSC.edu
ccdt_ebm_neamati-sh_001 Neamati Nouri Department of Medicinal Chemistry University of Michigan Ann Arbor MI USA

Dr. Nouri Neamati is a John G. Searle Professor of Medicinal Chemistry at the University of Michigan College of Pharmacy. He obtained his Ph.D. in biomedical sciences from the University of Texas Graduate School of Biomedical Sciences and M.D. Anderson Cancer Center, Houston. He was a postdoctoral and a research fellow at the National Institutes of Health (1995-2000). Dr. Neamati later joined the University of Southern California, rising to the rank of professor in 2011. He is also a recipient of numerous awards, including the NIH Technology Transfer Award in 2000, STOP CANCER Award in 2001, GlaxoSmithKline Drug Discovery Award in 2002, BCRP and LCRP Concept Awards from the Department of Defense (DOD) in 2005 and 2009.

neamati@umich.edu neamati@med.umich.edu
ccdt_ebm_workman-sh_001 Workman Paul Division of Cancer Therapeutics, Cancer Research UK Cancer Therapeutics Unit The Institute for Cancer Research Surrey England, UK

Prof. Paul Workman is a Chief Executive and President of The Institute of Cancer Research (ICR).  Prof. Workman is a passionate advocate of personalized molecular medicine and is an enthusiastic practitioner of multidisciplinary cancer drug discovery and development approaches to ‘drugging the cancer genome’. He has established and successfully led drug discovery project teams. Professor Workman’s personal and collaborative research utilizes molecular pharmacology and chemical biology approaches, including high-throughput and genome-wide as well as hypothesis- driven strategies, to interrogate cancer biology, identify and validate new drug targets, discover and develop chemical tools and drugs acting on these targets, identify predictive and mechanism of action biomarkers, and elucidate mechanisms of drug sensitivity of resistance.

Paul.Workman@icr.ac.uk
Regional Editors North America ccdt_ebm_teicher-sh_001 Teicher Beverly A. Molecular Pharmacology Branch National Cancer Institute Bethesda MD USA

Dr. Beverly A. Teicher is a Chief of the Molecular Pharmacology Branch at NCI, since early 2011. Her team focuses on target and drug discovery for rare and recalcitrant cancers such as sarcoma and small cell lung cancer. She completed her PhD in Bioorganic Chemistry from the Johns Hopkins University and received her postdoctoral training at Yale University School of Medicine. She joined Dana-Farber Cancer Institute as an Assistant Professor of Pathology and rose to Associate Professor of Medicine and Radiation Therapy, Harvard Medical School at Dana-Farber Cancer Institute and Joint Center for Radiation Therapy. She later joined Cancer Drug Discovery at Lilly Research Laboratories where she founded and chaired the Tumor Microenvironment Action Group.

Beverly.Teicher@nih.gov teicherba@mail.nih.gov
Country Editor ccdt_ebm_grunt_001 Grunt Thomas W. Division of Oncology, Department of Medicine I Medical University Vienna (MUV) Vienna Austria

Dr. Grunt obtained a doctorate (Ph.D.) in Cell Biology from the University of Salzburg, Austria. Dr. Grunt also holds a Master of Science in Experimental Biology from the University of Salzburg. Currently he is also an Associate Professor in the Medical University of Vienna, Austria. He has published more than 80 scientific publications and is a named inventor of several U.S patents. Dr. Grunt received several awards from the International Society of Differentiation (ISD), the Austrian Association of Clinical Oncology and from the Austrian Society of Hematology and Oncology. He is member of the American Association of Cancer Research (AACR), the European Association of Cancer Research (EACR), the International Society of Differentiation (ISD), the International Society of Cancer Metabolism (ISCaM), and the Union for International Cancer Control (UICC).

thomas.grunt@meduniwien.ac.at
ccdt_ebm_Sheikh-sh_001 Sheikh M.S. Department of Pharmacology SUNY Upstate Medical University Syracuse NY USA

Dr. M. Saeed Sheikh is a professor in the Department of Pharmacology at the State University of New York, Upstate Medical University, Syracuse, New York, USA. His research activities are focused on the development of tumor markers and targets for cancer therapy. Dr. Sheikh is also involved in a research to elucidate the molecular mechanisms, regulating cell death, and survival signaling in normal and cancer cells to better understand the processes of cancer development and progression and to develop novel, more efficacious and less toxic anticancer agents along with the investigation in a related area of cellular responses to genotoxic, ER and metabolic stresses.

sheikhm@upstate.edu
Section Editors ccdt_ebm_Dou-ab_001 Anticancer Drugs and Mechanisms of Action Dou Q. Ping Departments of Oncology, Pharmacology and Pathology Wayne State University School of Medicine Detroit,MI USA

Dr. Q. Ping Dou is Professor of Oncology, Pharmacology and Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI. He obtained his B.S. degree in chemistry from Shandong University in 1981, Ph.D. degree in chemistry from Rutgers University in 1988, and postdoctoral training at Dana-Farber Cancer Institute and Harvard Medical School from 1988 to 1993. Dr. Dou has extensive experience in the fields of molecular targeting, drug discovery, chemoprevention, natural products, proteasome inhibitors, cell cycle and apoptosis, and has published ~268 peer-reviewed research and review articles, many of those have been published in journals of the highest quality.

ccdt_ebm_Palikaras-sa_001 Palikaras Konstantinos Orcid Department of Basic Medical Sciences National and Kapodistrian University of Athens Athens Greece

Konstantinos Palikaras is an Assistant Professor of Experimental Physiology at the Medical School of the National and Kapodistrian University of Athens, Greece. He is a molecular biologist who has a great experience in energy metabolism, autophagy and aging. His research focuses on studies of autophagy, mitophagy and cellular homeostasis investigating the role of energy metabolism in neuronal physiology and survival. His main interests are the molecular mechanisms of necrotic and mitophagic cell death and their interplay between cellular metabolism and aging, and the development of novel genetic tools for biomedical research. For his scientific accomplishments, Konstantinos Palikaras has received several notable scientific prizes including a “Fotis Kafatos” Award for excellence in biology from Hellenic Society of Bioscientists, DeLill Nasser Award for Professional Development in Genetics from Genetic Society of America and Manasaki Doctoral Fellowship from the University of Crete. He is also a member of the Genetics Society of America (GSA) and the Hellenic Society of Biochemistry and Molecular Biology (HSBMB).

0000-0001-6992-5560 35330366600 Autophagy palikarask@imbb.forth.gr
ccdt_ebm_li_001 Li Hongliang School of Medicine Wuhan University Wuhan China

Dr. Hongliang Li is a professor of medicine at Wuhan University. He has served as the Director of Model Animal Hubei Engineering Research Center, Director of Hubei Model Animal Research Center, and acting director of Cardiovascular Research Institute. His research interests focus on nonalcoholic fatty liver disease and cardiovascular diseases. Dr. Li has published over 200 peer reviewed papers in highly impacted journals including Nat Med, Cell Metab., Annu Rev Pathol., Physiol Rev., Circulation, etc. His current H-index according to Google Scholar is 55 with more than 100000 citations.

Hepatology 420102@whu.edu.cn
ccdt_ebm_Yao_001 Yao Xudong Department of Urology Tongji University School of Medicine Shanghai China

Dr. Xudong Yao, received his PhD degree in medicine in Tianjin Medical University, China. He completed post-doctoral training in Fudan University, China. He is currently a Professor and the Director of Department of Urology, Shanghai Tenth People’s Hospital, Tongji University. Dr. Yao has published more than 50 international peer-reviewed papers and authored several book chapters. His research focuses on tumor diagnosis, treatment, and pathogenesis, including bladder cancer, prostate cancer, and renal cell carcinoma. He is the member of Chinese Medical Association, Chinese Society of Clinical Oncology, American Urological Association, and European Association of Urology.

Cancer Biomarkers yaoxudong078@sina.com
ccdt_ebm_To_001 To Kenneth School of Pharmacy The Chinese University of Hong Kong Shatin New Territories Hong Kong

Kenneth To is currently an Associate Professor at School of Pharmacy, The Chinese University of Hong Kong, Hong Kong. He received post-doctoral research training at National Cancer Institute (NCI, NIH) and Johns Hopkins University in the United States. His research focuses on multidrug resistance (MDR) to cancer chemotherapy. He exploited the use of specific inhibitor of MDR transporters and epigenetic drugs to overcome cancer drug resistance and to improve the efficacy of chemotherapy. In recent years, his team has also successfully repurposed non-oncology drugs to overcome resistance to targeted anticancer agents in the treatment of lung cancer.

Chemoresistance kennethto@cuhk.edu.hk
ccdt_ebm_Cheng_001 Cheng Simon Department of Radiation Oncology Columbia University Irving Medical Center New York City NY USA

Dr. Simon Cheng is a physician-scientist in radiation oncology as an Assistant Professor at Columbia University Irving Medical Center and a member of Columbia’s Herbert Irving Comprehensive Cancer Center. He is recognized nationally in thoracic oncology and brain tumors and his research group is dedicated to developing innovative strategies to make treatment more effective and improve patient care.

Lung Cancer sc3225@cumc.columbia.edu
Neuro-Oncology and Glioblastoma ccdt_ebm_Nardone_001 Nardone Valerio Department of Precision Medicine University of Campania “L. Vanvitelli” Naples Italy

Dr. Valerio Nardone graduated in Medicine and Surgery from the University of Siena. He started the Residency School of Radiation Oncology and specialized in clinical management of cancer patients, performing both chemotherapy and radiotherapy. He obtained a Master’s Degree in Radiotherapy and new drugs: biology and clinic at Brescia University. He is working as a Researcher Type B (Tenure-track for Associate Professor) at University of Campania “L. Vanvitelli” in Naples. He is an author and co-author of more than 54 papers in peer-reviewed journals, as well oral communications and posters in international and national congresses. Dr. Nardone’s contribution to radiotherapy and oncology focuses on different diseases, such as brain cancer, lung cancer, prostate cancer and gastrointestinal cancer.

v.nardone@hotmail.it
Cancer Genomics and Epigenetic ccdt_ebm_Wang-ning_001 Wang Ning School of Chinese Medicine The University of Hong Kong Pok Fu Lam Hong Kong

Dr. Wang Ning, received his bachelor degree in biochemistry from Sun Yat-Sen University (2006, China), Mphil degree in pharmaceutical science from Sun Yat-Sen University (2008, China) and PhD degree in pharmacology from the University of Hong Kong (2012, Hong Kong) and continued his post-doctoral training at the same University. He is now Assistant Professor in the School of Chinese Medicine. Since 2006, Dr. Wang has published more than 100 international peer-reviewed papers and over 50 abstracts and conference proceedings in the field of pharmacology of natural products and Traditional Chinese Medicine. He serves on the editorial boards of BMC complementary and alternative medicine, World Journal of Stem Cells and Frontiers in Pharmacology. He is the member of European Association of Cancer Research.

ckwang@hku.hk
Cancer Genomics and Epigenetics ccdt_ebm_Panagiotis-sh_001 Vlachostergios Panagiotis J. Department of Medicine Weill Cornell Medicine New York NY USA

Dr. Panagiotis J. Vlachostergios MD PhD is an Assistant Professor in the Department of Medicine, Division of Hematology and Medical Oncology, Weill Medical College of Cornell University, New York, NY, USA. He received his Ph.D. in Cancer Biology in 2013. He has published more than 70 international peer-reviewed articles, and authored several book chapters and abstracts. His research has been highly cited, and he is a recipient of prestigious awards from the American Society of Clinical Oncology, European Society of Medical Oncology, Society for Translational Oncology, American Federation for Medical Research, Bladder Cancer Advocacy Network, and others. He serves as an investigator on CDMRP-funded and industry-sponsored clinical studies

pjv9003@med.cornell.edu
ccdt_ebm_caraglia-sh_001 Caraglia Michele Department of Precision Medicine University of Campania "L. Vanvitelli" Naples Italy

Dr. Caraglia is a Full Professor of Biochemistry at the School of Medicine of the University of Campania “L. Vanvitelli” in Naples (Italy) (UniCampania). He has served as President of the Italian Association of Cell Cultures and Coordinator of the Signal Transduction and Nucleotides Sequencing Laboratory at the Department of Precision Medicine at UniCampania. He is an author of more than 460 articles on internationally peer-reviewed journals with a Scopus H index of 60, author of several internationally issued patents. He has also served as the Editorial Board member of several international peer-reviewed Journals. His research activity is focused on non coding RNAs as therapeutics and diagnostics and on the delivery of drugs in tumours through the use of nanocarriers.

michele.caraglia@unicampania.it Non-coding RNAs
ccdt_ebm_Qadir-sh_001 Qadir Muhammad I. College of Pharmacy Institute of Molecular Biology and Biotechnology Bahauddin Zakariya University Multan Pakistan

Dr. Qadir has developed a new cost-effective and convenient method for diagnosis of cancer named as “Qadir test”. Dr. Qadir has also invented two anti-HIV drugs that may be used as prophylaxis or for the treatment of AIDS, especially for Pakistani’s patients. Dr. Qadir has worked to evaluate the pharmacological activities of local plants. He discovered the use of many local plants for cancer, jaundice/hepatitis, hypertension, asthma, diabetes, spasm, ulcer, fever, diarrhea, and infectious diseases of bacterial and fungal origin. Dr. Qadir has also worked on the isolation and structure elucidation of bioactive substances from medicinal plants and has resulted in the discovery of several new/novel natural compounds. Dr. Qadir has patents for Preparations containing locally isolated bacteriophages (Qadirphages) with their antibacterial activity. Dr. Qadir has increased the efficacy of many drugs with the use of nanotechnology and polymer-technology and has identified different biological and pharmacological pathways which are important for diagnosis and management of different diseases. He has more than 190 publications, making an impact factor more than 100, and has supervised02 PhD and 35 M Phil theses.

mrimranqadir@hotmail.com Oncology-Virology Interface
ccdt_ebm_metwally-nh_001 Metwally Nadia H. Chemistry department Cairo University Giza Egypt nhmmohamed@yahoo.com Chemistry in Cancer Drug Discovery ccdt_ebm_ilhan-mutlu_001 Ilhan-Mutlu Aysegül Department of Medicine Medical University of Vienna Vienna Austria

Dr. Ilhan-Mutlu is presently serving as the director of the Gastroesophageal Tumors Unit” of the Department of Oncology, MUV. She graduated from Medical University. Her PhD is focused on the characterization of the hypothetical gene. She started her residency in internal medicine at the department of Oncology. She received “Transitional Research Grant’’ of the European Society of Medical Oncology and completed postdoctoral at the German Cancer Research Center.

aysegul.ilhan@meduniwien.ac.at Translational Immunotherapy
ccdt_ebm_xu-c_001 Xu Chuan Sichuan Cancer Hospital & Institute University of Electronic Science and Technology of China Chengdu China

Dr. C. Xu received his Doctoral degree from the Third Military Medical University (TMMU), China. Following his clinical and research training in internal medicine and preventive medicine at TMMU. He completed a postdoctoral research fellowship in cancer stem cell research at the Institute of Pathology and Southwest Cancer Center, Southwest hospital, TMMU. He is currently a Professor of Sichuan Cancer Hospital & Institute, School of Medicine, University of Electronic Science and Technology of China. His research interests include the self-renewal mechanism of cancer stem cell, tumor microenvironment, protein posttranslational modifications in signaling and immune regulation of cancer. He has published more than 30 papers and gained strong expertise and experience in studying protein-protein interaction and signal transduction. Dr. Xu has provided numerous services to the scientific community and beyond, his current services include the members of the Committee of Neoplastic Supportive Care, Chinese Anti-Cancer Association and Experts Committee on Education for Cancer Patients, Chinese Society of Clinical Oncology.

Molecular and Translational Oncology xuchuan100@163.com
Editorial Board Members ccdt_ebm_Naidu_001 Naidu Rakesh Jeffrey Cheah School of Medicine and Health Sciences Monash University Malaysia Selangor Darul Ehsan Malaysia

Dr. Rakesh Naidu has been appointed as an Associate Professor in biomedical sciences at the Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia. His current research focuses on the molecular biology of cancer, cancer therapeutics and cancer venomics. His research group focuses on the identification and understanding of the underlying molecular mechanisms of synthetic compounds and analogues derived from natural compounds as well as natural components from venoms that contribute to anti-cancer activities in human cancer cells such as lung, prostate, colon, breast and glioblastoma. He has published peer-reviewed research papers in several international and national journals and book chapters in cancer.

rakesh.naidu@monash.edu
ccdt_ebm_chai_001 Chai Jianyuan Orcid Baotou Medical College Inner Mongolia University of Science and Technology Baotou China 0000-0001-6975-6867

Dr. Chai received his Ph.D. from the City University of New York in 1998 and completed his postdoctoral training at Harvard University in 2001. Then he served the Department of Veterans Affairs of the USA as a Principal Investigator (2002-2016), in affiliation with the University of California in Irvine. Currently, he is a professor at Baotou Medical College, Inner Mongolia University of Science and Technology. He has published dozens of science articles in a broad field, from zoology to cancer biology. He has been a member of AGA, AHA, and ASBMB, and the editorial board of multiple journals.

jianyuan.chai@gmail.com
ccdt_ebm_Bozko-sh_001 Bozko Przemyslaw Department of Internal Medicine Eberhard Karls University of Tubingen Tubingen Germany

Przemyslaw Bozko received his Ph.D. from the University of Gdansk, Poland in 2003. After several postdocs he became the Lab head of the Dept. Internal Medicine at Tübingen University Hospital, Tübingen, Germany since 2012. His research interests include interactions between tumor suppressors and oncogenes, during tumor formation and anticancer therapy.

Przemyslaw.Bozko@med.uni-tuebingen.de
ccdt_ebm_song-k-as_001 Song Kedong Dalian R&D Centre for Stem Cells and Tissue Engineering, State Key Lab of Fine Chemicals Dalian University of Technology Dalian China

Dr. Kedong Song is currently Professor in Dalian R&D Centre for Stem Cells and Tissue Engineering, State Key Lab of Fine Chemicals, Dalian University of Technology. Prof. Song obtained a PhD degree from Dalian University of Technology. He was a Post‐doctoral research associate in Department of Chemical Engineering, Imperial College London from 2008 to 2009. He became a full professor in 2016 at Dalian University of Technology in the areas of 3D tumor models, Stem Cells, Tissue Engineering and Pharmaceutical Chemistry. Prof. Song has published over 100 papers on international journals, and has got citation more than 2,500 times.

kedongsong@dlut.edu.cn
ccdt_ebm_lin-s-as_001 Lin Shuibin First Affiliated Hospital Sun Yat-sen University Guangzhou China

Dr. Lin is currently a Principal Investigator/Professor at the First Affiliated Hospital in Sun Yat-sen University, Guangzhou, China. His lab works on RNA modifications, cancers and stem cells related diseases.

linshb6@mail.sysu.edu.cn
ccdt_ebm_Kamal-sh_001 Kamal Mohammad A. King Fahd Medical Research Center King Abdulaziz University Jeddah Saudi Arabia

Prof. Dr. Mohammad Amjad Kamal is a Distinguished Adjunct Professor at the King Fahd Medical Research Center (KFMRC), King Abdulaziz University, Saudi Arabia, where he was full Professor from March 2011 to March 2013. He is leading a highly productive global collaborative research team based from Novel Global Community Educational Foundation (NGCEF), Australia. Dr. Kamal's biochemical research in the field of Alzheimer’s disease, Type 2 diabetes and leukemia has culminated in more than 500 publications in internationally respected journals, and 65 abstracts at international conferences. Prof. Kamal migrated to Australia in 1998 and was awarded a prestigious U2000 Postdoctoral Fellowship in 2000 by the University of Sydney, School of Molecular and Microbial Biosciences. Moreover, he is serving as a regional/editorial member/guest editor of several reputed scientific journals - this is undertaken on an honorable basis.

prof.ma.kamal@gmail.com
ccdt_ebm_y-Xie-sh_001 Xie Yingqiu Department of Biology Nazarbayev University Astana Kazakhstan

Yingqiu Xie is an Associate Professor of Biology. He received a Ph.D. in genetics. Dr. Xie’s research interests include cancer drug targets, cell signaling, biomarkers, cancer genetics, cancer recurrence, drug resistance and experimental therapeutics, especially in prostate cancer and leukemia. Recently Dr. Xie has carried out the research on nanotechnology and herbal medicine in cancer signaling and pharmacology. Dr. Xie has been qualified for Ph.D. supervisor and has been a supervisor of several M.S. students. He has been serving as reviewer and Editorial Board member for several journals.

xieautumnus@gmail.com xieautumnus@yahoo.com, yingqiu.xie@nu.edu.kz
ccdt_ebm_barreca-d_001 Barreca Davide Orcid Department of Chemical, Biological, Pharmaceutical and Environmental Sciences Università di Messina Messina Italy 0000-0002-1463-4069 56477413700 X-6802-2018 https://www.ncbi.nlm.nih.gov/pubmed/?term=BARRECA+DAVIDE https://scholar.google.it/citations?user=sbYKCdcAAAAJ&hl=it&oi=ao

Davide Barreca is an Assistant Professor of biochemistry at the University of Messina. He specializes in enzyme modulation by natural compounds, inhibition of protein aggregation and activation of signal apoptotic cascade. Most of his research projects concentrate on separation and identification of unknown flavonoids, structural-activity elucidation, and biochemical analysis of their health promoting or cytotoxicity properties on cell culture. He is author of over 90 papers in peer-reviewed journals, 30 chapters in books, and 70 conference proceedings and reviewer of over 40 international scientific journals.

dbarreca@unime.it
ccdt_ebm_cheung-lwt_001 Cheung Lydia W.T. School of Biomedical Sciences The University of Hong Kong Pokfulam Hong Kong

Dr. Cheung is an assistant professor in the School of Biomedical Sciences, University of Hong Kong. The focus of her research is functional characterization of genomic abnormalities in cancers (with a goal of ultimately devising the optimal therapeutic strategies for cancer patients). Her research revolutionizes the concept underlying precision cancer therapy (where mutations of the same cancer gene may have different functional impact and confer sensitivity to different drugs). She has published in Cancer Cell, Cancer Discovery, Cancer Research, Nature Communications, Genome Research, etc.

lydiacwt@hku.hk
ccdt_ebm_prosperi_001 Prosperi Ennio Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” CNR, Istituto di Genetica Molecolare Pavia Italy

Dr. Prosperi graduated in Biological Sciences at the University of Pavia (Italy) and performed PhD studies in Physiological Sciences at the University of Milano, and in the Histochemistry Dept. of Leiden University” (Nederland). Dr. Prosperi is a Senior Researcher at the Institute of Molecular Genetics of the Italian National Research Council (CNR), lab of Genome Stability and DNA damage response, with more than 100 publications. Formerly, Lecturer in Physiopathology of the Cell Cycle, in the Medical Faculty of Pavia University, Dr. Prosperi is currently a teacher in the PhD program in “Genetics, Molecular and Cellular Biology” (Pavia University).

prosperi@igm.cnr.it ennio.prosperi@igm.cnr.it
Marchetti Philippe French Institute of Health and Medical Research University of Lille Lille France philippe.marchetti@inserm.fr ccdt_ebm_kuroda_001 Kuroda Junya Division of Hematology and Oncology, Department of Medicine Kyoto Prefectural University of Medicine Japan

Junya Kuroda, holder of M.D. and Ph.D. degrees, is an associate professor at the Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine in Kyoto, Japan, and has published more than 120 articles.

Junya Kuroda’s research interests focused on the identification of the disease–specific dysregulation of epigenetics, genetics, cytogenetics, and cell signaling, to develop novel therapeutic strategies and biomarkers for cancers, especially hematologic malignancies, such as leukemias, lymphomas, or myeloma, while also covers clinical researches in hematological oncology.

Junkuro@koto.kpu-m.ac.jp
ccdt_ebm_Juan-Carlos_001 Lacal Juan C. CSIC (Spanish Research Council) Instituto de Investigaciones Biomédicas Madrid Spain

Juan Carlos Lacal is a doctor in Biology from the Autonomous University of Madrid. He completed his postdoctoral training at the NCI with scholarships from EMBO and the Fogarty International Center and as Visiting Associate at the LCMB, NCI. He is a Research Professor at CSIC. He worked as a Secretary General and President of ASEICA, member of the Executive Committees of FESEO and the EACR, member of the Council of FECS and Council of the EACR as a member and Chairman. He is an inventor of 16 patent families with 92 applications and the scientific promoter of two spin-off companies focused on cancer diagnosis and treatment. He is actually a member of the Advisory Council of MEDES of the Lilly Foundation, member of the Scientific Advisory Board of INCLIVA and Expert of the European Commission. He has published over 200 papers in journals, books, and monographs with an H index of 63 and over 12,000 citations. His major contribution is the discovery of choline kinase as a new biomarker and drug target in oncology and other human diseases.

jclacal@iib.uam.es
ccdt_ebm_breccia_001 Breccia Massimo Hematology, Department of Translational and Precision Medicine University of Rome “Sapienza” Rome Italy

Dr. Massimo Breccia is assistant physician at Sapienza University of Rome, Azienda Policlinico Umberto I. His scientific interests and publications as author or co-author are mainly focused on biological and clinical aspects of acute and chronic myeloid leukemias and myelodysplastic syndromes. He is a peer-reviewer for several journals such as Blood, Haematologica, Leukemia Research, British Journal of Haematology, etc. and editorial board member of 5 journals Leukemia Research, Leukemia Research and Treatment, Hematology Reviews, etc.. He is a member of SIE, SIES, EHA and participates as a study coordinator in several clinical trials for CML, AML and MDS. He is the secretary of GIMEMA QoL Working Party. He has more than 300 papers in peer reviewed journals.

breccia@bce.uniroma1.it
Au Jessie L.-S. Ohio State University Columbus OH USA jau@optimumtx.com Barchi Joseph J. Jr Center for Cancer Research National Cancer Institute Frederick MD USA barchi@helix.nih.gov Carty Michael P. Centre for Chromosome Biology National University of Ireland Galway City Ireland michael.carty@nuigalway.ie Denny William A. Faculty of Medical and Health Sciences The University of Auckland Auckland New Zealand

Professor William A Denny gained a PhD in chemistry at the University of Auckland and, following positions at Oxford University and UC San Diego, returned to the University of Auckland as director of the Auckland Cancer Society Research Centre. In this capacity, with co-workers and commercial partners (including three co-founded startup companies), he has brought 14 new drugs to clinical trials for cancer and infectious diseases, with 3 to date approved. This work is reported in 740 scientific publications and 114 patent families. Honours include the ACS Medicinal Chemistry award and the UK Royal Society of Chemistry Adrien Albert Medal.

b.denny@auckland.ac.nz
ccdt_ebm_ferguson_001 Ferguson Lynn Faculty of Medical & Health Sciences, Discipline of Nutrition University of Auckland Auckland New Zealand

Prof Ferguson obtained a D. Phil. (Oxon,) from the University of Oxford. On her return to New Zealand, she got connected with some anticancer drug developer, who were developing the Auckland Cancer Society Research Centre, University of Auckland, New Zealand. Lynnette had become interested in applying her genetics training to an understanding of adverse genetic effects of novel drugs. She joined the Cancer Research Centre to set up the Centre for Mutagen Testing, which still functions to test anticancer drugs, novel pharmaceutical products and occupational situations as caner hazards in New Zealand. Her studies on causes of cancer have led to a significant amount of work on the New Zealand diet, and she maintains a dual interest in drugs and nutrients in the treatment and cause of cancer.

l.ferguson@auckland.ac.nz
He Tong-Chuan Department of Surgery The University of Chicago Medical Center Chicago IL USA tche@bsd.uchicago.edu tche@uchicago.edu ccdt_ebm_huang_001 Huang Chuanshu Nelson Institute of Environmental Medicine New York University School of Medicine NY USA

Chaunshu Huang is a Professor of Department of Environmental Medicine and Biochemistry and Molecular Pharmacology and Urology, and Deputy Director of Nelson Institute of Environmental medicine, New York University School of Medicine. Dr. Huang has published more than 280 research papers with total citations over 11,200. Chuanshu’s major research addresses fundamental questions concerning the responses of mammalian cells to environmental carcinogens at the levels of protein kinases, transcription factors and their target genes, as well as protein modification both in vitro and in vivo. His research also includes elucidation of tumor invasion and metastasis, as well as screening and identifying novel anti-cancer drugs and the molecular mechanisms underlying their anti-cancer effect.

chuanshu.huang@nyumc.org chuanshu@env.med.nyu.edu
Lakshmanaswamy Rajkumar Texas Tech University Health Sciences Center at El Paso Texas TX USA rajkumar.lakshmanaswamy@ttuhsc.edu Liu Jing-Yuan Indiana University-Purdue University at Indianapolis Indianapolis IN USA jliu2@iupui.edu ccdt_ebm_Mukhopadhyay_001 Mukhopadhyay Debabrata Department of Biochemistry and Molecular Biology, and Department of Biomedical Engineering Mayo Clinic Cancer Center, Mayo Clinic Rochester MN USA

Debabrata (Dev) Mukhopadhyay, Ph.D.: Professor of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Jacksonville, Florida, has a joint appointment with the Department of Physiology and Biomedical Engineering. Before moving to Mayo Clinic as Professor 14 years ago, he was research fellow and later independent investigator followed by as an Associate Professor at Harvard Medical School, Boston. He has carried out angiogenesis and tumor microenvironment related research and also leading translational nanomedicine programs including new drug delivery systems. He has been serving as reviewer for several study sections in NIH and agencies. Recently, he has been appointed as the Florida Department of Health Cancer Research Chair. He has published more than 190 peer-reviewed papers in different journals including Nature, Nature Medicine, Cancer Cell, Cancer Research, Nano Letters. He has several patents and has been involved to develop different start up companies in the area of therapy and diagnosis of the disease

Mukhopadhyay.Debabrata@mayo.edu
Njar Vincent C.O. Dept. of Pharmacology-Head, Medicinal Chemistry Section University of Maryland School of Medicine Baltimore MD USA VNjar@som.umaryland.edu ccdt_ebm_patrone_001 Patrone Franco Department of Hemato-Oncology University of Genova Genova Italy

Dr. Franco Patrone MD obtained specialization degrees in General Medicine, Hematology, and Oncology from the University of Genova, Italy. Currently Dr. Patrone is an adjunct professor of Internal Medicine in the Department of Internal Medicine, University of Genova. He has published more than 170 scientific publications reported on PubMed. Dr. Patrone has been, director of the first Medical Clinic and of the Department of Internal Medicine, University of Genoa, as well as of the Internal Medicine and Oncology Clinic and of the Department of Hematology and Oncology, San Martino University Hospital, Genoa, Italy.

fpatrone@unige.it
ccdt_ebm_pommier_001 Pommier Yves Division of Basic Sciences, NCI National Cancer Institute Bethesda MD USA

Yves Pommier is the Chief of the Developmental Therapeutics Branch, NCI. He obtained his M.D. and Ph.D. from the University of Paris, and has studied DNA topoisomerases and the pharmacology of their inhibitors for the past 30 years. Three of his topoisomerase I inhibitors are in clinical trials. Dr. Pommier also discovered the first HIV-1 integrase inhibitors and the mechanism of action of poly(ADPribose) polymerase inhibitors by trapping PARP-DNA complexes. He pioneered the concept of drugs acting as interfacial inhibitors.

pommier@nih.gov PommierY@mail.nih.gov, yves.pommier@nih.gov
ccdt_ebm_sarkadi_001 Sarkadi Balazs Biomembrane Laboratory Natural Sciences Research Center National Medical Center Budapest Hungary

Balázs Sarkadi, MD, Ph.D., spent several years as a post-doc and then as a visiting scientist at major universities in the United States and Canada. He is research professor at Semmelweis University, member of the Hungarian Academy of Sciences, past president of FEBS, member of several international research societies including the Academia Europeae. His research has been focusing on membrane proteins, including the investigation of ABC membrane transporters, which play a major role in the multidrug resistance of cancer, in general pharmacology, and in stem cell function. He has published more than 250 papers in international scientific journals, with a citation number over 13,000.

sarkadi@biomembrane.hu
Scala Stefania Oncological Immunology National Cancer Institute "G. Pascale" Naples Italy scalaste@unina.it ccdt_ebm_srivenugopal_001 Srivenugopal Kalkunte S. Department of Biomedical Sciences Texas Tech University Health Sciences Center Amarillo Texas USA

Dr. Kalkunte Srivenugopal obtained his Ph.D. in Biochemistry from the Indian Institute of Science. He is currently a tenured Professor of Biomedical Sciences at the Texas Tech University School of Pharmacy in Amarillo, Texas, USA. Dr. Srivenugopal’s research interests include brain tumor chemotherapy, DNA repair, drug discovery, p53 biology and redox signaling. He has received funding from the National Institutes of Health, Cancer Prevention Research Institute of Texas and many private foundations. He has published more than 85 peer-reviewed articles.

Kalkunte.Srivenugopal@ttuhsc.edu
Tsao George S.W. Department of Anatomy, Faculty of Medicine University of Hong Kong Pok Fu Lam Hong Kong gswtsao@hkucc.hku.hk Wang Wei School of Pharmacy Hunan University of Chinese Medicine Hunan China wangwei402@hotmail.com ccdt_ebm_Weygant_001 Weygant Nathaniel Academy of Integrative Medicine Fujian University of Traditional Chinese Medicine Fuzhou China

Dr. Nathaniel Weygant is a Professor at Fujian University of Traditional Chinese Medicine. His interests include investigating the role of epithelial-immune crosstalk in cancer, identifying subpopulations of cancer patients vulnerable to cancer progression, understanding gender differences in cancer and identifying therapies to target CSCs. His previous work included investigating the functional role of the DCLK1 CSC marker, role of intestinal epithelia in the inflammatory response, the development of miRNA/mRNA oncology biomarkers and the development of therapeutic monoclonal antibodies. Dr. Weygant performed his undergraduate studies at the University of Oklahoma (Oklahoma, USA) and obtained his PhD from the University of Portsmouth (Portsmouth, UK).

nweygant@gmail.com
Zhang Lin Department of Pharmacology & Chemical Biology University of Pittsburgh Pittsburgh PA USA

Dr. Zhang is a Professor of Pharmacology and Chemical Biology at UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine. He received his PhD in Molecular Biology from University of Southern California and had postdoctoral training with Dr. Bert Vogelstein at Johns Hopkins. He has been studying mechanisms of cell death in colorectal cancer therapy and prevention. Dr. Zhang has authored over 140 research and review articles with over 25,000 citations and H-index of 61. He has served as a standing member of the NIH DMP study section and editorial boards of Cancer Research and other journals.

zhanglx@upmc.edu
Associate Editorial Board Members ccdt_ebm_Wang-Weiwei_001 Wang Weiwei Geneis (Beijing) Co., Ltd Beijing China

Dr. Weiwei Wang received his Doctoral degree from Beijing institute of Genomics, Chinese Academy of Sciences. He finished his post-doctoral training and worked as a research associate at the University of Alberta in Canada. Currently he is serving as a CTO, Vice President, R&D Director in Geneis (Beijing) Co. His main research areas are IVD assay development/related translational studies including cancer related ctDNA/cfRNA identification using NGS/nanopore sequencing; clinical metagenomics; virome enrichment and sequencing; single-cell multi-omics; microfluidic-chip based assays. Dr. Wang has published more than 30 peer-reviewed papers/book chapters in the journals related to oncology, virology, immunology, metagenomics, genomics, proteomics, etc.

wangww@geneis.cn
ccdt_Hettie-sh_001 Hettie Kenneth S. Orcid Department of Radiology Stanford University School of Medicine Stanford CA USA 0000-0002-0607-7944 55783013800

Dr. Hettie is an NCI/NIH Ruth L. Kirschstein NRSA Fellow (PI/PD) in the Departments of Radiology and Otolaryngology-Head & Neck Surgery within the School of Medicine at Stanford University that specializes in the design, development, and implementation of near-infrared-I/II peptidyl-, nucleic acid-, and immuno-based activatable bio-/molecular probes, biosensors, theranostics, and nanoparticles targeting biomarkers of brain cancers and their tumor microenvironment for their early detection, direct visualization, and surgical removal via utilizing image-guided surgery. He focuses on their rational design, bio-/chemical synthesis, and bio-/analytical evaluation of novel diagnostics and therapeutics in basic science research, preclinical, and clinical setting.

khettie@stanford.edu
Executive Guest Editor(s) ccdt_ebm_Wang-sa_003 Wang Junpu Department of Pathology Xiang-ya Hospital Changsha China

Dr. Pu has been working in the Department of Pathology, Xiang-ya Hospital, Central South University since 2009. His main research topics are, basic and clinical research of gastrointestinal tumor pathology/Ultramicroscopic pathology/Mitochondrial encephalomyopathy. At present, more than 40 teaching and scientific research papers have been published, among them, multiple SCI papers have been published as the first author/corresponding author. Apart from that, has presided over more than 10 projects including the National Natural Science Foundation of China, the Postdoctoral Science Foundation of China, the Natural Science Foundation of Hunan Province (Youth and General project), and the Postgraduate and Undergraduate Education Reform Projects, and has obtained more than 20 national patents. Guest reviewer of several SCI journals. Besides, he is also a member of a number of societies such as Chinese Society of Pathology, Chinese Research Hospital Association, Member of Hunan Pathology Society, Committee member of Hunan Neuroscience Society etc. He has 16 publications to his credit.

ccdt_ebm_Liu_003 Liu Qiang Nanjing Medical University Nanjing China doctorlvqiang@njmu.edu.cn Li Yinghua Guangzhou Women and Children’s MedicalCenter Guangzhou Medical University Guangzhou China

Dr. Yinghua Li is currently serving as a professor in the Center laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. He and his group members are currently interested in functionalized nanomaterials in anticancer and antivirus, Targeted drug delivery; siRNA for cancer treatment; Mechanisms of multidrug resistance; Apoptosis signal transduction; Anticancer and antivirus molecular mechanisms;. He has contributed more than 80 peer reviewed papers in international journals such as Nano Today, Redox Biology, Materials Today, Drug Delivery, Small, Journal of Biomedical science and Current Cancer Drug Targets.

liyinghua@gzhmu.edu.cn
ccdt_bacolod_md-sa_001 Bacolod Manny D. Department of Microbiology and Immunology Weill Cornell Medical College New York, NY USA

Dr. Manny D. Bacolod is currently an Assistant Professor of Microbiology and Immunology at Weill Cornell Medical College (New York, NY). After earning his Ph.D. in Chemistry from the University of Connecticut, he has held various research positions at Duke University Medical Center, Weill Cornell Medical College, Brigham and Women’s Hospital, and Virginia Commonwealth University. Dr. Bacolod’s contribution to cancer literature encompasses a wide range of topics including colon cancer genomics and biomarker discovery, epigenetics, cancer genetics, brain tumor drug resistance, chemical mutagenesis, cancer metastasis, and immuno oncogenomics.

mdb2005@med.cornell.edu
ccdt_ebm_he-y_001 He Yonghan Kunming Institute of Zoology Chinese Academy of Sciences Kunming China

Dr. Yonghan He received his M.D. degree from Harbin Medical University in China. He finished his post-doctoral training at the University of Arkansas for Medical Sciences, and University of Florida in the USA. He is presently serving as an Associate professor of Kunming Institute of Zoology, Chinese Academy of Sciences. Dr. He focuses on studying the mechanisms involved in cancer cell death, and developing small molecules or natural compounds that suppress tumor cell growth. He is also very interested in studying cellular senescence and developing senolytics that can selectively kill senescent cells to improve the health of aged individuals. Dr. He has published more than 50 peer-reviewed papers in journals related to cancer or aging.

heyonghan-2008@163.com heyonghan@mail.kiz.ac.cn
ccdt_ebm_liu-g-ah_001 Liu Guangwei Institute of Cell Biology, College of Life Sciences Beijing Normal University Beijing China

Dr. Guangwei Liu is currently serving as a professor in the Key Laboratory of Cell Proliferation and Regulation, Ministry of Education, Beijing Normal University, Beijing, China. He and his group members are currently interested in understanding the molecular and cellular mechanisms for positive and negative regulation of T cell immune function, exploring the possibility for clinical application of anti-tumor immunotherapy and anti-infection, as well as establishing protocols to induce transplant immune tolerance. He has contributed more than 70 peer reviewed papers in international journals such as Immunity, Nature Immunology, Nature Communications, PNAS, Blood, Journal of Immunology and Cancer Research.

liugw@bnu.edu.cn lab919@163.com
ccdt_ebm_konig-h-ah_001 Konig Heiko Department of Hematology and Oncology Indiana University Melvin and Bren Simon Cancer Center Indianapolis IN USA

Dr. Heiko Konig is presently serving as an Assistant Professor at the Indiana University Melvin & Bren Simon Cancer Center in Indianapolis where his effort is dedicated to the care of patients with acute myeloid leukemia (AML) and other hematological malignancies, and laboratory based research with a focus on the role of hypoxia in the development of AML drug resistance and minimal residual disease. He received his MD and doctoral degrees from the medical schools at the Ludwig Maximilians University Munich and the Philipps University Marburg/ Germany, respectively. He is also serving as the co-chair of the Big Ten Cancer Research Consortium (BTCRC) Myeloid Malignancies Clinical Trial Working Group and the Hoosier Cancer Research Network (HCRN) Lymphoma/Leukemia Clinical Trial Working Group.

hkonig@iupui.edu
ccdt_ebm_tuchin-w-ah_001 Tuchin Valery V. Department of Physics Institute of Precision Mechanics and Control of the RAS Saratov State University Saratov Russia

Dr. Valery V. Tuchin is presently serving as a Professor and Chair of Optics and Biophotonics at Saratov University (National Research University of Russia). He is also the head of Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control, RAS, and the supervisor of Interdisciplinary Laboratory of Biophotonics at Tomsk State University (National Research University of Russia) and Laboratory of FemtoMedicine of ITMO University (National Research University of Russia). His research interests include tissue optics, laser medicine, tissue optical clearing, and nanobiophotonics. He has published more than 700 papers (Web of Science), 27 monographs and text-books, and 58 book chapters. Dr. Tuchin is also a holder of more than 50 patents.

tuchinvv@mail.ru
ccdt_ebm_Wu-sa-ah_001 Wu Fanglong Department of General and Emergency Medicine Sichuan University Chengdu China

Dr. Fanglong Wu, M.D., Ph.D. is an Associate professor in the Department of Oral Medicine and Department of General and Emergency Medicine, Sichuan University, Chengdu, China. He is also the Deputy Director in the Department of Conservative Dentistry and Oral Medicine, Sichuan University, Chengdu, China. He completed his Ph.D in Oral and Maxillofacial Surgery from 2012-2015, and another Ph.D in Oral Medicine from 2015-2018, both from Sichuan University, China. His interests and expertise are: Head and Neck Cancer, Tumor Immunology, Tumor Microenvironment, Cancer Targeted Therapy and TGF-beta Signal Transduction. He has 21 publications to his credit. In 2019, he delivered an invited lecture on "TGF-βRII regulates glucose metabolism in oral cancer-associated fibroblasts", at the 4th Meeting of the International Association for Dental Research Asia Pacific Region, Speaker, Queensland, Australia.

wufanglong@scu.edu.cn
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