Synthesis of NIR Emitting Rare Earth Doped Fluorapatite Nanoparticles for Bioimaging Applications

(E-pub Ahead of Print)

Author(s): Easwaradas Kreedapathy Girija* , S. Karthi , D. Karthickraja , Gangadharan Ajithkumar , Dhiraj Kumar Sardar , Chidangil Santhosh .

Journal Name: Current Physical Chemistry

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In this study, biocompatible rare-earth ions co-doped luminescent fluorapatite (FAp) nanosystems such as Yb/Er FAp and Nd/Yb FAp were synthesized by microwave assisted wet precipitation and hydrothermal methods, respectively. Trisodium citrate was used as an organic modifier for the synthesis. In the case of Nd/Yb FAp the host matrix absorption and emission was oberved, hence Nd/Yb was synthesized without citrate. On heat treatment of this for optical activation studies, when the Yb3+ concentration was increased to 10 mol %, the YbPO4 secondary phase was found to appear. Although, the Yb/Er FAp system resulted in large grain growth, no such grain growth was observed in Nd/Yb FAp and the grains were within the nano size regime even after heat treatment. For optical studies, Yb/Er FAp system was excited at 980 nm and Nd/Yb FAp at 800 nm. Both the systems showed successful energy transfer from sensitizer to activator with a quantum yield of 74 % for Yb/Er FAp and energy transfer efficiency of 71 % for Nd/Yb FAp system. Both the samples were found to be cytocompatible and has the potential for using as probes for bioimaging applications.

Keywords: Rare earth doped nanoparticles, Fluorapatite, Hydrothermal method, Microwave method, NIR emission, Biocompatibility, Bioimaging

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(E-pub Ahead of Print)
DOI: 10.2174/1877946809666190708131511

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