Human Oral Defensins Antimicrobial Peptides: A Future Promising Antimicrobial Drug

Author(s): Zohaib Khurshid, Muhammad S. Zafar*, Mustafa Naseem, Rabia Sannam Khan, Shariq Najeeb.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 10 , 2018


The nature and structural composition of antimicrobial peptides are derived from their innate immune response and they are active against various bacteria, fungi and other microorganisms. The aim of this paper was to pool up the literature on the features of human oral defensins antimicrobial peptides. The defensins showed antimicrobial activity against Gram-positive and Gram-negative bacteria and various fungi and viruses. As with their other properties like antiviral, antifungal and antibacterial, human defensins peptides are thought to have a unique amino acid-based structure with Disulphide Bridge which makes them synthesize chemically or naturally with the help of these bacteria. The data contributing in this study was gathered from the research papers published in English language in the last twenty-five years. This literature mainly elaborates the general and analytical characteristics of antimicrobial peptides in the human oral cavity; focusing on the types, biochemistry, and mechanism of action of defensins with its clinical importance.

Keywords: Antimicrobial peptides, defensins, oral cavity, peptides, proteins, innate immune.

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Article Details

Year: 2018
Page: [1130 - 1137]
Pages: 8
DOI: 10.2174/1381612824666180403114615
Price: $58

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PDF: 24
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