The nature and structural composition of antimicrobial peptides are derived from their innate immune
response and they are active against various bacteria, fungi and other microorganisms. The aim of this paper was
to pool up the literature on the features of human oral defensins antimicrobial peptides. The defensins showed
antimicrobial activity against Gram-positive and Gram-negative bacteria and various fungi and viruses. As with
their other properties like antiviral, antifungal and antibacterial, human defensins peptides are thought to have a
unique amino acid-based structure with Disulphide Bridge which makes them synthesize chemically or naturally
with the help of these bacteria. The data contributing in this study was gathered from the research papers published
in English language in the last twenty-five years. This literature mainly elaborates the general and analytical
characteristics of antimicrobial peptides in the human oral cavity; focusing on the types, biochemistry, and
mechanism of action of defensins with its clinical importance.
Keywords: Antimicrobial peptides, defensins, oral cavity, peptides, proteins, innate immune.
Rights & PermissionsPrintExport