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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Paneth Cells and their Antimicrobials in Intestinal Immunity

Author(s): Timon E. Adolph, Lisa Mayr, Felix Grabherr and Herbert Tilg*

Volume 24 , Issue 10 , 2018

Page: [1121 - 1129] Pages: 9

DOI: 10.2174/1381612824666180327161947

Price: $65

Abstract

Since the initial description of granular-rich small-intestinal crypt-based epithelial cells in 1872, today referred to as Paneth cells, a plethora of recent studies underlined their function in intestinal homeostasis. Paneth cells are evolutionary conserved highly secretory cells that produce antimicrobials to control gut microbial communities. Moreover, Paneth cells emerged as stem cell regulators that translate environmental cues into intestinal epithelial responses. Paneth cell disturbances may instigate intestinal inflammation and provide susceptibility to infection. Altered Paneth cell functions have been associated with a variety of inflammatory disease models and were linked to human intestinal disease processes including inflammatory bowel diseases such as Crohn´s disease and ulcerative colitis. This review summarizes our current understanding of Paneth cells and their antimicrobials in health and disease.

Keywords: Paneth cells, antimicrobials, intestinal inflammation, inflammatory bowel disease, gut microbiota, epithelial cells.


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