Immobilization of biomolecules in porous supports, especially in silica matrices, is probably one of
the most successful processes in biomaterials synthesis in the last three decades. The flexibility and versatility
offered by the sol-gel process, ensured its leading position in the biomolecules immobilization. Functionalization
with organic groups of the silica precursors leads to so-called organically modified silica gels. While there
are many studies published recently about organically modified silica gels, the relationship between the functionalized
support properties and the biomolecules activity is still poorly understood. The aim of this review is
to summarize the available results on the influence of the organic functionalization of the silica support on the
performance of immobilized biomolecules.
Keywords: sol-gel technique, organically modified silica, biomolecule encapsulation, catalysis, silica matrices, silica gels.
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