Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications

Author(s): Yong Siang Ong, Liqian Gao, Karunakaran A. Kalesh, Zhiqiang Yu*, Jigang Wang, Chengcheng Liu, Yiwen Li, Hongyan Sun*, Su Seong Lee*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 20 , 2017

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Abstract:

Cyclic peptides, owing to their good stability, high resistance to exo- and to some extent endo-peptidases, enhanced binding affinity and selectivity towards target biomolecules, are actively investigated as biochemical tools and therapeutic agents. In this review, we discuss various commonly utilized synthetic strategies for cyclic peptides and peptoids (peptidomimetics), their important screening methods to identify the bioactive cyclic peptides and peptoids such as combinatorial beadbased peptide library, phage display, mRNA display etc. and recent advances in their applications as bioactive compounds. Lastly, we also make a summary and provide an outlook of the research area.

Keywords: Cyclic peptide, Cyclization, Bead-based library, Phage display, mRNA display, Computational.

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Article Details

VOLUME: 17
ISSUE: 20
Year: 2017
Page: [2302 - 2318]
Pages: 17
DOI: 10.2174/1568026617666170224121658
Price: $58

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