Anionic Linear Globular Dendrimer-G2-Ciprofloxacin Nano-Conjugate: Novel Agent against Wilson Disease Cell Model
Narges Karimi, Mohammad Reza Aghasadeghi, Parichehr Yaghmaei, Hadi Fathi Moghaddam, Nasser Nassiri-Koopaei, Hamid Moloudian, Saleh Najafi, Seyed Ataaollah Shandiz and Mehdi Shafiee Ardestani
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Inherited defect of the gene ATP7B causes malexcretion of copper in the bile and leads to several complications
that need treatment to deplete it from organs. Current therapy of Wilson disease, D-penicillamine has very serious side effects
and drug with optimum therapeutic effects and minimum side effects is of importance. In the present study ciprofloxacin
was conjugated with an anionic globular dendrimer to lower the intracellular copper concentration. The results
showed its efficacy and safety to certain levels. Based on the results, ciprofloxacin-anionic linear globular dendrimer conjugate
can be a useful option to reduce intracellular copper concentration and an investigational therapeutic agent in Wilson
Copper, Dendrimer-ciprofloxacin nano-particle, Fluoroquinolone, Metal ions, Wilson disease.
Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.