Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring
Olga Bortolini, Iqbal Mulani, Antonio De Nino, Loredana Maiuolo, Alessandro Melicchio, Beatrice Russo and Donatella Granchi
Affiliation: Dipartimento di Chimica e Tecnologie Chimiche, Via P. Bucci, cubo 12C, Universita della Calabria, Rende (Italy).
A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive
cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.
Keywords: Apolipoprotein E, bisphosphonates, gem-phosphonate-phosphate rearrangement, isoxazolidines, ring opening, transition-metal
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