Synthesis and Biological Evaluation of Piperazinyl-2-(Benzo)thiophen/- furan-2-yl-acetonitriles as Strecker Reaction Products
Rahul V. Patel,
Jigar K. Patel,
Shivraj H. Nile,
Se Won Park.
Single step construction of heterocyclic α-aminonitriles has been carried out using Indium Powder as catalyst in
water medium via Strecker reaction methodology. The multicomponent reaction products were examined for their
inhibitory potential against two Gram-positive bacteria (S. aureus and B. cereus), three Gram-negative bacteria (E. coli, P.
aeruginosa and K. pneumoniae) and two fungal species (A. niger and C. albicans). The biological screening identified that
the some compounds were found to possess promising antimicrobial (6.25-50 μg/mL of MIC) potential. A structure–
activity relationship (SAR) study was explored to facilitate further development of this new class of compounds. The
structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR spectroscopy and elemental
Keywords: Thiophehe, Furan, piperazine, Indium powder, Catalyst, Antimicrobial activity
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