A large library of oxazine derivatives is obtained by Betti’s reaction between activated phenols, amines and
aryl aldehyde. The present paper deals with the multi component microwave assisted an efficient and expeditious reaction
between 7-hydroxy-4-methylcoumarin as an activated phenolic moiety, substituted benzaldehyde and primary aromatic
amines. All the Betti’s bases were synthesized by using green chemical approach. The proposed structures of the oxazine
derivatives were characterized and confirmed by using spectral analyses viz., 1H-NMR, 13C-NMR, IR and mass spectra;
and also tested for their antibacterial activity.