Adhesion of Osteoblasts to a Vertically Aligned TiO2 Nanotube Surface

Author(s): Ekaterina Gongadze, Doron Kabaso, Sebastian Bauer, Jung Park, Patrik Schmuki, Ales Iglic.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 2 , 2013

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The adhesion of cells to vertically aligned TiO2 nanotubes is reviewed. The attraction between a negatively charged nanotube surface and a negatively charged osteoblast is facilitated by charged protein-mediators like proteins with a quadrupolar internal charge distribution, fibronectin and vitronectin. It is shown that adhesion and spreading of osteoblasts on vertically aligned TiO2 nanotube surfaces depend on the diameter of the nanotubes. Apparently, a small diameter nanotube surface has on average more sharp convex edges per unit area than a large one, leading to stronger binding affinity on its surface.

Keywords: TiO2 nanotube surfaces, adhesion, dynamic simulations, nanostructured surface topography, osteoblast adhesion

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Article Details

Year: 2013
Page: [194 - 200]
Pages: 7
DOI: 10.2174/1389557511313020002
Price: $58

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