Synthesis and Antioxidant Evaluation of Schiff Bases Derived from 2,6- Pyridinedicarboxylic Acid

Author(s): Maja Molnar, Milan Cacic, Sanja Zec Zrinusic.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 6 , 2012

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A series of novel Schiff bases derived from dipicolinic acid was synthesized and evaluated for antioxidant and iron chelating activity. In most cases Schiff bases derived from di-hydrazide showed higher antioxidant activity than the ones derived from mono-hydrazide and some of them are very promising considering the fact of being better antioxidants than the standards used in the investigation. For iron chelating activity substituents had a greater impact on the activity than mono or di-hydrazide skeleton.

Keywords: Antioxidant, dipicolinic acid, metal chelating, Schiff base, Clostridium, Bacillus, antibacterial, antifungal, antitumor, pharmaceutical

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Article Details

Year: 2012
Page: [401 - 410]
Pages: 10
DOI: 10.2174/157017812801322480
Price: $65

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