Abstract
Brain tumors are one of the most lethal forms of cancer. They are extremely difficult to treat. Although, the rate of brain tumor incidence is relatively low, the field clearly lacks therapeutic strategies capable of overcoming barriers for effective delivery of drugs to brain tumors. Clinical failure of many potentially effective therapeutics for the treatment of brain tumors is usually not due to a lack of drug potency, but rather can be attributed to shortcomings in the methods by which a drug is delivered to the brain and into brain tumors. In response to the lack of efficacy of conventional drug delivery methods, extensive efforts have been made to develop novel strategies to overcome the obstacles for brain tumor drug delivery. The challenge is to design therapeutic strategies that deliver drugs to brain tumors in a safe and effective manner. This review provides some insight into several potential techniques that have been developed to improve drug delivery to brain tumors, and it should be helpful to clinicians and research scientists as well.
Keywords: brain tumors, cancer, malignant gliomas, glioblastoma multiforme, anaplastic astrocytoma
Current Pharmaceutical Design
Title: Drug Delivery Systems for Brain Tumor Therapy
Volume: 10 Issue: 12
Author(s): Jarkko Rautioa and Prashant J. Chikhale
Affiliation:
Keywords: brain tumors, cancer, malignant gliomas, glioblastoma multiforme, anaplastic astrocytoma
Abstract: Brain tumors are one of the most lethal forms of cancer. They are extremely difficult to treat. Although, the rate of brain tumor incidence is relatively low, the field clearly lacks therapeutic strategies capable of overcoming barriers for effective delivery of drugs to brain tumors. Clinical failure of many potentially effective therapeutics for the treatment of brain tumors is usually not due to a lack of drug potency, but rather can be attributed to shortcomings in the methods by which a drug is delivered to the brain and into brain tumors. In response to the lack of efficacy of conventional drug delivery methods, extensive efforts have been made to develop novel strategies to overcome the obstacles for brain tumor drug delivery. The challenge is to design therapeutic strategies that deliver drugs to brain tumors in a safe and effective manner. This review provides some insight into several potential techniques that have been developed to improve drug delivery to brain tumors, and it should be helpful to clinicians and research scientists as well.
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Cite this article as:
Rautioa Jarkko and Chikhale J. Prashant, Drug Delivery Systems for Brain Tumor Therapy, Current Pharmaceutical Design 2004; 10 (12) . https://dx.doi.org/10.2174/1381612043384916
DOI https://dx.doi.org/10.2174/1381612043384916 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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