Abstract
Dendrimers are a new class of artifical macromolecules with well-defined hyperbranched structures which endue these promising materials with a wide variety of applications. They are useful tools in drug discovery and allow bio-active molecules to be presented in a highly multi-valent fashion on the surface. Recently, the use of dendrimers as scaffolds of carbohydrates to synthesize glycodendrimers with high and specific affinities to various receptors has made it possible for these dendritic materials to participate in extracellular and intracellular biochemical processes. References on synthesis and biological applications of glycodendrimers in the literatures demonstrate that dendrimers are suitable candidates as scaffolds of these bioactive carbohydrates. In this mini-review, different approaches to construct glycodendrimers as well as their promising applications in biological systems are fully discussed.
Keywords: PAMAM dendrimers, click chemistry, HIV-1, glycocluster, neoglycoconjugates
Current Drug Discovery Technologies
Title: Design, Synthesis and Potent Pharmaceutical Applications of Glycodendrimers:A Mini Review
Volume: 4 Issue: 4
Author(s): Yiwen Li, Yiyun Cheng and Tongwen Xu
Affiliation:
Keywords: PAMAM dendrimers, click chemistry, HIV-1, glycocluster, neoglycoconjugates
Abstract: Dendrimers are a new class of artifical macromolecules with well-defined hyperbranched structures which endue these promising materials with a wide variety of applications. They are useful tools in drug discovery and allow bio-active molecules to be presented in a highly multi-valent fashion on the surface. Recently, the use of dendrimers as scaffolds of carbohydrates to synthesize glycodendrimers with high and specific affinities to various receptors has made it possible for these dendritic materials to participate in extracellular and intracellular biochemical processes. References on synthesis and biological applications of glycodendrimers in the literatures demonstrate that dendrimers are suitable candidates as scaffolds of these bioactive carbohydrates. In this mini-review, different approaches to construct glycodendrimers as well as their promising applications in biological systems are fully discussed.
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Cite this article as:
Li Yiwen, Cheng Yiyun and Xu Tongwen, Design, Synthesis and Potent Pharmaceutical Applications of Glycodendrimers:A Mini Review, Current Drug Discovery Technologies 2007; 4 (4) . https://dx.doi.org/10.2174/157016307783220503
DOI https://dx.doi.org/10.2174/157016307783220503 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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