Abstract
Vitamin E is known to improve antioxidant status, but the effect of vitamin E on bone quality in orchidectomized rats is unknown. In the present study, thirty-two 1-y-old male rats were randomized to two groups: a sham-control group (n=8) and an orchidectomized group (n=24). The orchidectomized group was divided into three groups of eight and assigned to one of the following treatments: orchidectomy (ORX), low-dose vitamin E of 65.6 mg/Kg diet or high-dose vitamin E of 656 mg/Kg diet. Four months after the study began, all rats were killed, blood was collected, and plasma was harvested for antioxidant status, tartrate resistant acid phosphatase (TRAP), and IGF-I. Orchidectomy decreased (P < 0.05) plasma antioxidant and IGF-I, reduced bone (P < 0.05) quality and bone strength, increased (P < 0.05) plasma TRAP and urinary excretion of calcium and magnesium compared to the sham-control group. In contrast to ORX, vitamin E increased (P < 0.05) plasma antioxidant and had no beneficial effect on indices of bone quality, bone resorption and bone formation marker, or urinary calcium and magnesium excretion. In conclusion, vitamin E appears to decrease oxidative stress without improving bone quality in orchidectomized rats.
Keywords: Antioxidants, oxidative stress, vitamin E, bone
Current Nutrition & Food Science
Title: Vitamin E does not Support Bone Quality in Orchidectomized Rats
Volume: 3 Issue: 4
Author(s): Farzad Deyhim, Claudia Garcia, Arnulfo Villarreal, Kristi Garcia, Ryan Rios, Cheri Gonzales, Kranthi Mandadi, Bahram Faraji and Bhimanagouda S. Patil
Affiliation:
Keywords: Antioxidants, oxidative stress, vitamin E, bone
Abstract: Vitamin E is known to improve antioxidant status, but the effect of vitamin E on bone quality in orchidectomized rats is unknown. In the present study, thirty-two 1-y-old male rats were randomized to two groups: a sham-control group (n=8) and an orchidectomized group (n=24). The orchidectomized group was divided into three groups of eight and assigned to one of the following treatments: orchidectomy (ORX), low-dose vitamin E of 65.6 mg/Kg diet or high-dose vitamin E of 656 mg/Kg diet. Four months after the study began, all rats were killed, blood was collected, and plasma was harvested for antioxidant status, tartrate resistant acid phosphatase (TRAP), and IGF-I. Orchidectomy decreased (P < 0.05) plasma antioxidant and IGF-I, reduced bone (P < 0.05) quality and bone strength, increased (P < 0.05) plasma TRAP and urinary excretion of calcium and magnesium compared to the sham-control group. In contrast to ORX, vitamin E increased (P < 0.05) plasma antioxidant and had no beneficial effect on indices of bone quality, bone resorption and bone formation marker, or urinary calcium and magnesium excretion. In conclusion, vitamin E appears to decrease oxidative stress without improving bone quality in orchidectomized rats.
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Cite this article as:
Deyhim Farzad, Garcia Claudia, Villarreal Arnulfo, Garcia Kristi, Rios Ryan, Gonzales Cheri, Mandadi Kranthi, Faraji Bahram and Patil S. Bhimanagouda, Vitamin E does not Support Bone Quality in Orchidectomized Rats, Current Nutrition & Food Science 2007; 3 (4) . https://dx.doi.org/10.2174/1573401310703040300
DOI https://dx.doi.org/10.2174/1573401310703040300 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
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