Abstract
To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.
Keywords: Vanadyl compound, insulinomimetic activity, diabetes mellitus, blood circulation monitoring-electron, paramagnetic resonance (BCM-EPR), pharmacokinetic analysis, bioavailability, enteric-coated capsule
Mini-Reviews in Medicinal Chemistry
Title: Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use
Volume: 4 Issue: 1
Author(s): H. Sakurai, J. Fugono and H. Yasui
Affiliation:
Keywords: Vanadyl compound, insulinomimetic activity, diabetes mellitus, blood circulation monitoring-electron, paramagnetic resonance (BCM-EPR), pharmacokinetic analysis, bioavailability, enteric-coated capsule
Abstract: To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.
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Cite this article as:
H. Sakurai , J. Fugono and H. Yasui , Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use, Mini-Reviews in Medicinal Chemistry 2004; 4 (1) . https://dx.doi.org/10.2174/1389557043487574
DOI https://dx.doi.org/10.2174/1389557043487574 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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