Abstract
Novel techniques for drug delivery have been investigated in human medicine in recent years. The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. One long-standing approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants) that can reversibly compromise the skins barrier function and consequently allow the entry of otherwise poorly penetrating molecules into the membrane and through to the systemic circulation. A large number of fatty acids have been used as permeation enhancers. They have proven to be effective and safe sorption promoters. This present review includes the classification, feasibility and application of fatty acids as sorption promoters for improved delivery of drug through skin.
Keywords: Transdermal, permeation enhancers, fatty acids, oleic acid
Current Drug Delivery
Title: Status of Fatty Acids as Skin Penetration Enhancers-A Review
Volume: 6 Issue: 3
Author(s): Ashu Mittal, U. V.S. Sara, Asgar Ali and Mohd. Aqil
Affiliation:
Keywords: Transdermal, permeation enhancers, fatty acids, oleic acid
Abstract: Novel techniques for drug delivery have been investigated in human medicine in recent years. The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. One long-standing approach for improving transdermal drug delivery uses penetration enhancers (also called sorption promoters or accelerants) that can reversibly compromise the skins barrier function and consequently allow the entry of otherwise poorly penetrating molecules into the membrane and through to the systemic circulation. A large number of fatty acids have been used as permeation enhancers. They have proven to be effective and safe sorption promoters. This present review includes the classification, feasibility and application of fatty acids as sorption promoters for improved delivery of drug through skin.
Export Options
About this article
Cite this article as:
Mittal Ashu, Sara V.S. U., Ali Asgar and Aqil Mohd., Status of Fatty Acids as Skin Penetration Enhancers-A Review, Current Drug Delivery 2009; 6 (3) . https://dx.doi.org/10.2174/156720109788680877
DOI https://dx.doi.org/10.2174/156720109788680877 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
Call for Papers in Thematic Issues
Advancements in Robotic and AI-based Drug Discovery and Delivery for Neurological Disorders
Neurological disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, and brain tumors, pose significant challenges in drug delivery due to the blood-brain barrier's intricate structure and the complexity of neuronal networks. Traditional drug delivery methods often fall short in reaching therapeutic concentrations within the central nervous system, limiting treatment efficacy and ...read more
Advances of natural products, bio-actives and novel drug delivery system against emerging viral infections
Due to the increasing prevalence of viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compounds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable ...read more
Electrospun Fibers as Drug Delivery Systems
In recent years, electrospun fibers have attracted considerable attention as potential platforms for drug delivery due to their distinctive properties and adaptability. These fibers feature a notable surface area-to-volume ratio and can be intentionally designed with high porosity, facilitating an increased capacity for drug loading and rendering them suitable for ...read more
Emerging Nanotherapeutics for Mitigation of Neurodegenerative Disorders
Conditions affecting the central nervous system (CNS) present a significant hurdle due to limited access of both treatments and diagnostic tools for the brain. The blood-brain barrier (BBB) acts as a barrier, restricting the passage of molecules from the bloodstream into the brain. The most formidable challenge facing scientists is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Meet Our Editorial Board Member:
Current Diabetes Reviews Nucleic Acid-Based Aptamers: Applications, Development and Clinical Trials
Current Medicinal Chemistry Interactions of Biologically Active Factors and Vascular Mediators During Hypertension in Pregnancy
Current Hypertension Reviews The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure
Current Hypertension Reviews Endothelial Dysfunction in Cardiac Allograft Vasculopathy: Potential Pharmacological Interventions
Current Vascular Pharmacology Molecular Rationales for Signal Transduction Therapy and Chemoprevention of BRCA1-Related Breast and Ovarian Tumours
Current Signal Transduction Therapy Skeletal Muscle in Cancer Cachexia: The Ideal Target of Drug Therapy
Current Cancer Drug Targets Wound with Diabetes: Present Scenario and Future
Current Diabetes Reviews Conference Report:
CNS & Neurological Disorders - Drug Targets Evaluation of Human Pharmacokinetics, Therapeutic Dose and Exposure Predictions Using Marketed Oral Drugs
Current Drug Metabolism Pharmacology and Therapeutic Potential of Sigma1 Receptor Ligands
Current Neuropharmacology Edaravone (3-Methyl-1-Phenyl-2-Pyrazolin-5-one), A Novel Free Radical Scavenger, for Treatment of Cardiovascular Diseases
Recent Patents on Cardiovascular Drug Discovery The Role of Antiplatelet Agents in the Management of Patients Receiving Intracardiac Closure Devices
Current Pharmaceutical Design Transungual Drug Delivery System for the Topical Treatment of Onychomycosis: A Review
Drug Delivery Letters Microbubbles Contrast Agents: General Overview as Diagnostics and Therapeutic Agent
Current Drug Targets Roles of Hematopoietic Stem and Progenitor Cells in Ischemic Cardiovascular Disease
Current Stem Cell Research & Therapy Blocking Receptor Protein Tyrosine Phosphatase β /ζ: A Potential Therapeutic Strategy for Parkinsons Disease
Current Medicinal Chemistry Editorial [Hot Topic: Stem Cell Based Therapy for Autoimmunity (Guest Editor: Frank Alderuccio)]
Current Stem Cell Research & Therapy An UPLC-MS/MS Method for Routine Quantification of Insulin Degludec in Plasma
Current Pharmaceutical Analysis A Progressive Review of V600E-B-RAF-Dependent Melanoma and Drugs Inhibiting It
Mini-Reviews in Medicinal Chemistry