Abstract
Among the most important insights into coronary and inflammatory disease is that the formation of vessel occluding placques is its essence an inflammatory process, that is counteracted by anti-inflammatory drugs Current therapeutical options of dealing with the increased challenge to public health posed by increased vessel disease are limited and unsatisfactory. Disturbingly, an increasing cohort of patients does not react to the immunosuppressive drugs available. Importantly, however, space travel is associated with well-tolerated immunosuppression and thus identification of the molecular mechanisms underlying this space travel-associated immunosuppression may have significant benefit for directing clinical research on earth. Devising an experimental set up for investigating the molecular details of space flightinduced immunosuppression is, however, fraught with difficulties. Two recent ESA-sponsored space missions (the Delta Taxi flight to ISS and Maser 10 sounding rocket mission) have now shown that these technical hurdles can be successfully tackled.
Keywords: centrifuges, cellular kinases, LPS, immune cells, immunosuppression
Current Genomics
Title: Using Microgravity for Defining Novel Anti-Atherosclerotic Therapy
Volume: 6 Issue: 6
Author(s): A. Verhaar, K. K. Krishnadath and M. P. Peppelenbosch
Affiliation:
Keywords: centrifuges, cellular kinases, LPS, immune cells, immunosuppression
Abstract: Among the most important insights into coronary and inflammatory disease is that the formation of vessel occluding placques is its essence an inflammatory process, that is counteracted by anti-inflammatory drugs Current therapeutical options of dealing with the increased challenge to public health posed by increased vessel disease are limited and unsatisfactory. Disturbingly, an increasing cohort of patients does not react to the immunosuppressive drugs available. Importantly, however, space travel is associated with well-tolerated immunosuppression and thus identification of the molecular mechanisms underlying this space travel-associated immunosuppression may have significant benefit for directing clinical research on earth. Devising an experimental set up for investigating the molecular details of space flightinduced immunosuppression is, however, fraught with difficulties. Two recent ESA-sponsored space missions (the Delta Taxi flight to ISS and Maser 10 sounding rocket mission) have now shown that these technical hurdles can be successfully tackled.
Export Options
About this article
Cite this article as:
Verhaar A., Krishnadath K. K. and Peppelenbosch P. M., Using Microgravity for Defining Novel Anti-Atherosclerotic Therapy, Current Genomics 2005; 6 (6) . https://dx.doi.org/10.2174/138920205774482972
DOI https://dx.doi.org/10.2174/138920205774482972 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Stem Cell Factor Receptor/c-Kit as a Drug Target in Cancer
Current Cancer Drug Targets A Review of Depsipeptide and Other Histone Deacetylase Inhibitors in Clinical Trials
Current Pharmaceutical Design Mammary Development and Breast Cancer: The Role of Stem Cells
Current Molecular Medicine Polymer Drug Conjugates: Recent Advancements in Various Diseases
Current Pharmaceutical Design Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight
Current Neuropharmacology Subject Index To Volume 13
Current Medicinal Chemistry Mesenchymal Cells in the Treatment of Spinal Cord Injury: Current & Future Perspectives
Current Stem Cell Research & Therapy Proteasome Structure, Function, and Lessons Learned from Beta-Lactone Inhibitors
Current Topics in Medicinal Chemistry Synthesis of Cis-Fused Pyran Indolocarbazole Derivatives that Inhibit FLT3 Kinase and the DNA Damage Kinase, Checkpoint Kinase 1
Anti-Cancer Agents in Medicinal Chemistry Triterpene Derivatives as Inhibitors of Protein Involved in the Inflammatory Process: Molecules Interfering with Phospholipase A2, Cycloxygenase, and Lipoxygenase
Current Drug Targets Polysulfated/Sulfonated Compounds for the Development of Drugs at the Crossroad of Viral Infection and Oncogenesis
Current Pharmaceutical Design Old Drugs-Current Perspectives
Current Pharmacogenomics Heptahelical Receptors for Lysolipids in Lymphocytes as Targets for Therapeutic Intervention
Drug Design Reviews - Online (Discontinued) The Need for Diagnostic Criteria in Systemic Vasculitis
Current Immunology Reviews (Discontinued) A Review of Natural and Synthetic Antioxidants Important for Health and Longevity
Current Medicinal Chemistry Role of Tyrosine Phosphatase Inhibitors in Cancer Treatment with Emphasis on SH2 Domain-Containing Tyrosine Phosphatases (SHPs)
Anti-Cancer Agents in Medicinal Chemistry Haploidentical Stem Cell Transplantation in Childhood
Current Cancer Therapy Reviews Beyond Stressed Self: Evidence for NKG2D Ligand Expression on Healthy Cells
Current Immunology Reviews (Discontinued) Update on the Principles and Novel Local and Systemic Therapies for the Treatment of Non-Infectious Uveitis
Inflammation & Allergy - Drug Targets (Discontinued) Safer Vectors for Gene Therapy of Primary Immunodeficiencies
Current Gene Therapy