Abstract
Given the variable protective efficacy provided by Mycobacterium bovis BCG (Bacillus Calmette-Guerin), there is a concerted effort worldwide to develop better vaccines that could be used to reduce the burden of tuberculosis. Recombinant BCG (rBCG) are vaccine candidates that offer some potential in this area. In this paper, we will discuss the molecular methods used to generate rBCG, and the results obtained with some of these new vaccines as compared with the conventional BCG vaccine in diverse animal models. Tuberculosis vaccine candidates based on rBCG are promising candidates, and some of them are now being tested in clinical trials.
Keywords: Immunogenicity, preclinical, animal models, cytokine expression, antigen secretion
Current Molecular Medicine
Title: Recombinant BCG Vaccine Candidates
Volume: 7 Issue: 4
Author(s): Rogelio Hernandez-Pando, Mauricio Castanon, Clara Espitia and Yolanda Lopez-Vidal
Affiliation:
Keywords: Immunogenicity, preclinical, animal models, cytokine expression, antigen secretion
Abstract: Given the variable protective efficacy provided by Mycobacterium bovis BCG (Bacillus Calmette-Guerin), there is a concerted effort worldwide to develop better vaccines that could be used to reduce the burden of tuberculosis. Recombinant BCG (rBCG) are vaccine candidates that offer some potential in this area. In this paper, we will discuss the molecular methods used to generate rBCG, and the results obtained with some of these new vaccines as compared with the conventional BCG vaccine in diverse animal models. Tuberculosis vaccine candidates based on rBCG are promising candidates, and some of them are now being tested in clinical trials.
Export Options
About this article
Cite this article as:
Hernandez-Pando Rogelio, Castanon Mauricio, Espitia Clara and Lopez-Vidal Yolanda, Recombinant BCG Vaccine Candidates, Current Molecular Medicine 2007; 7 (4) . https://dx.doi.org/10.2174/156652407780831610
DOI https://dx.doi.org/10.2174/156652407780831610 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Intraocular Immune Mechanisms in Uveitis
Current Immunology Reviews (Discontinued) Bioluminescent Quantitation and Detection of Gene Expression During Infectious Disease
Combinatorial Chemistry & High Throughput Screening Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient
Current Drug Safety Thalidomide: A Banned Drug Resurged into Future Anticancer Drug
Current Drug Therapy Preface [Hot topic: Carbohydrates (Executive Editor: Istvan Toth)]
Mini-Reviews in Medicinal Chemistry Body Mass Index (BMI) and Cognitive Functions in Later Life
Current Alzheimer Research A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines
Current Medicinal Chemistry Synthesis and Evaluation of New 5-methylisoxazole-3-carboxamide Derivatives as Antitubercular Agents
Anti-Infective Agents Susceptibility of Periodontopathogenic and Cariogenic Bacteria to Defensins and Potential Therapeutic Use of Defensins in Oral Diseases
Current Pharmaceutical Design Microfluidics as an Emerging Platform for Tackling Antimicrobial Resistance (AMR): A Review
Current Analytical Chemistry A Comprehensive Review on Phytochemistry and Pharmacological Effects of Stinging Nettle (Urtica dioica)
Current Traditional Medicine QSAR and the Prediction of T-Cell Epitopes
Current Proteomics An Update on Natural Occurrence and Biological Activity of Chromones
Current Medicinal Chemistry Helicobacter pylori: An Overview on Antimicrobials and Drug Delivery Systems for its Eradication
Current Drug Delivery BM 212 and its Derivatives as a New Class of Antimycobacterial Active Agents
Current Medicinal Chemistry Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting
Current Medicinal Chemistry Dried Blood Spots: A New Tool for Tuberculosis Treatment Optimization
Current Pharmaceutical Design Gene Mining and Functional Genomics in Human Osteoarthritis
Current Genomics CAPi: Computational Model for Apicoplast Inhibitors Prediction Against Plasmodium Parasite
Current Computer-Aided Drug Design Advances in the Research of β-Ketoacyl-ACP Synthase III (FabH) Inhibitors
Current Medicinal Chemistry