Advances in the Research of β-Ketoacyl-ACP Synthase III (FabH) Inhibitors

H.      -J. Zhang; Z.      -L. Li; H.      -L. Zhu

Abstract

Fatty acid biosynthesis is essential for bacterial survival. In recent years, components of this biosynthetic pathway have aroused wide concern. β-Ketoacyl-acyl carrier protein synthase III (FabH) is a particularly attractive target which catalyzes the initial step of fatty acid biosynthesis. In this review, fatty acid biosynthesis, recent advances in the research of FabH as well as related inhibitors are reviewed. Finally, we also discuss the prospect and developmental trend of FabH inhibitors as anti-bacterial agents.

Keywords: anti-bacterial agents, fatty acid synthase (FAS), FabH, FabH inhibitors, Alkyl-CoA disulfides, Thiolactomycin derivatives, 1,2-Dithiole-3-(thi)ones derivatives, Dithiole-3-(thi)ones derivatives, Cerulenin derivatives, Indole derivatives, Benzoylaminobenzoic acid derivatives, Alkylsulfonyl derivatives, Thiazolidine-2-one 1, 1-dioxide derivatives