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Reviews on Recent Clinical Trials

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ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

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Research Article

Plasma Levels of MMPs and TIMP-1 in Patients with Osteoarthritis After Recovery from COVID-19

Author(s): Yuriy Tuharov, Daryna Krenytska, Tetiana Halenova, Larysa Kot, Nataliia Raksha, Olexii Savchuk, Larisa Prysiazhniuk, Ruzhena Matkivska, Tetyana Falalyeyeva* and Liudmyla Ostapchenko

Volume 18, Issue 2, 2023

Published on: 16 March, 2023

Page: [123 - 128] Pages: 6

DOI: 10.2174/1574887118666230131141608

Price: $65

Abstract

Background: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPS) play a key role in the pathogenesis of osteoarthritis (OA). Recent research showed the involvement of some MMPs in COVID-19, but the results are limited and contradictory.

Objective: In this study, we investigated the levels of MMPs (MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10) and TIMP-1 in the plasma of patients with OA after recovery from COVID- 19.

Methods: The experiment involved patients aged 39 to 80 diagnosed with knee OA. All study participants were divided into three research groups: the control group included healthy individuals, the group OA included patients with enrolled cases of OA, and the third group of OA and COVID-19 included patients with OA who recovered from COVID-19 6-9 months ago. The levels of MMPs and TIMP-1 were measured in plasma by enzyme-linked immunosorbent assay.

Results: The study showed a change in the levels of MMPs in patients with OA who had COVID- 19 and those who did not have a history of SARS-CoV-2 infection. Particularly, patients with OA who were infected with coronavirus established an increase in MMP-2, MMP-3, MMP-8, and MMP-9, compared to healthy controls. Compared to normal subjects, a significant decrease in MMP-10 and TIMP-1 was established in both groups of patients with OA and convalescent COVID-19.

Conclusion: Thus, the results suggest that COVID-19 can affect the proteolysis-antiproteolysis system even after a long postinfectious state and may cause complications of existing musculoskeletal pathologies.

Keywords: Osteoarthritis, COVID-19, SARS-CoV-2 infection, inflammation, matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMP-1), enzyme-linked immunosorbent assay.

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