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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

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Editorial

COVID-19 and Ehlers-Danlos Syndrome: The Dangers of the Spike Protein of SARS-CoV-2

Author(s): Ziad Fajloun, Christian Legros and Jean-Marc Sabatier*

Volume 23, Issue 3, 2023

Published on: 13 January, 2023

Article ID: e040123212375 Pages: 3

DOI: 10.2174/1871526523666230104145108

[1]
Zhao DY, Rock MB, Sandhu FA. Craniocervical stabilization after failed chiari decompression: A case series of a population with high prevalence of ehlers-danlos syndrome. World Neurosurg 2022; 161: e546-52.
[http://dx.doi.org/10.1016/j.wneu.2022.02.068] [PMID: 35192974]
[2]
Dadras O, Afsahi AM, Pashaei Z, et al. The relationship between COVID-19 viral load and disease severity: A systematic review. Immun Inflamm Dis 2022; 10(3): e580.
[http://dx.doi.org/10.1002/iid3.580] [PMID: 34904379]
[3]
SeyedAlinaghi S, Karimi A, Mojdeganlou H, et al. Impact of COVID-19 pandemic on routine vaccination coverage of children and adolescents: A systematic review. Health Sci Rep 2022; 5(2): e00516.
[http://dx.doi.org/10.1002/hsr2.516] [PMID: 35224217]
[4]
Fajloun Z, Kovacic H, Annweiler C, Wu Y, Cao Z, Sabatier JM. SARS-CoV-2-induced neurological disorders in symptomatic COVID-19 and long COVID patients: Key role of brain renin-angiotensin system. Infect Disord Drug Targets 2022; 22(5): e060422203203.
[http://dx.doi.org/10.2174/1871526522666220406124618] [PMID: 35388764]
[5]
Khazaal S, Harb J, Rima M, et al. The pathophysiology of long COVID throughout the renin-angiotensin system. Molecules 2022; 27(9): 2903.
[http://dx.doi.org/10.3390/molecules27092903] [PMID: 35566253]
[6]
Mao G, Kopparapu S, Jin Y, et al. Craniocervical instability in patients with Ehlers-Danlos syndrome: Controversies in diagnosis and management. Spine J 2022; 22(12): 1944-52.
[http://dx.doi.org/10.1016/j.spinee.2022.08.008] [PMID: 36028216]
[7]
Kuivaniemi H, Tromp G. Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases. Gene 2019; 707: 151-71.
[http://dx.doi.org/10.1016/j.gene.2019.05.003] [PMID: 31075413]
[8]
Chohan K, Mittal N, McGillis L, et al. A review of respiratory manifestations and their management in Ehlers-Danlos syndromes and hypermobility spectrum disorders. Chron Respir Dis 2021; 18: 14799731211025313.
[http://dx.doi.org/10.1177/14799731211025313] [PMID: 34291699]
[9]
Hynes RO. Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 1992; 69(1): 11-25.
[http://dx.doi.org/10.1016/0092-8674(92)90115-S] [PMID: 1555235]
[10]
Bugatti A, Filippini F, Bardelli M, et al. SARS-CoV-2 infects human ACE2-negative endothelial cells through an αvβ3 integrin-mediated endocytosis even in the presence of vaccine-elicited neutralizing antibodies. Viruses 2022; 14(4): 705.
[http://dx.doi.org/10.3390/v14040705] [PMID: 35458435]
[11]
Norris EG, Pan XS, Hocking DC. Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist. bioRxiv 2022; 2022.04.11.487882.
[http://dx.doi.org/10.1101/2022.04.11.487882]
[12]
Buckley CD, Pilling D, Henriquez NV, et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature 1999; 397(6719): 534-9.
[http://dx.doi.org/10.1038/17409] [PMID: 10028971]
[13]
Annweiler C, Cao Z, Papon N, Kovacic H, Sabatier JM. Counter-regulatory renin-angiotensin system: An important line of research to understand and limit the severity of COVID-19. Infect Disord Drug Targets 2022; 22(2): e100921196331.
[http://dx.doi.org/10.2174/1871526521666210910063227] [PMID: 34515015]
[14]
Harb J, Debs N, Rima M, et al. SARS-CoV-2, COVID-19, and reproduction: effects on fertility, pregnancy, and neonatal life. Biomedicines 2022; 10(8): 1775.
[http://dx.doi.org/10.3390/biomedicines10081775] [PMID: 35892675]
[15]
Mehraeen E, Najafi Z, Hayati B, et al. Current treatments and therapeutic options for COVID-19 patients: a systematic review. Infect Disord Drug Targets 2022; 22(1): 62-73.
[http://dx.doi.org/10.2174/1871526521666210726150435] [PMID: 34313204]
[16]
El-Arif G, Farhat A, Khazaal S, et al. The renin-angiotensin system: a key role in SARS-CoV-2-induced COVID-19. Molecules 2021; 26(22): 6945.
[http://dx.doi.org/10.3390/molecules26226945] [PMID: 34834033]
[17]
El-Arif G, Khazaal S, Farhat A, et al. Angiotensin II Type I receptor (AT1R): The gate towards COVID-19-associated diseases. Molecules 2022; 27(7): 2048.
[http://dx.doi.org/10.3390/molecules27072048] [PMID: 35408447]
[18]
Othman H, Messaoud HB, Khamessi O, et al. SARS-CoV-2 spike protein unlikely to bind to integrins via the Arg-Gly-Asp (RGD) motif of the receptor binding domain: evidence from structural analysis and microscale accelerated molecular dynamics. Front Mol Biosci 2022; 9: 834857.
[http://dx.doi.org/10.3389/fmolb.2022.834857] [PMID: 35237662]
[19]
Beaudoin CA, Hamaia SW, Huang CLH, Blundell TL, Jackson AP. Can the SARS-CoV-2 spike protein bind integrins independent of the RGD sequence? Front Cell Infect Microbiol 2021; 11: 765300.
[http://dx.doi.org/10.3389/fcimb.2021.765300] [PMID: 34869067]
[20]
Cao Z, Wu Y, Faucon E, Sabatier JM. SARS-CoV-2 & COVID-19: Key-roles of the renin-angiotensin system/vitamin D impacting drug and vaccine developments. Infect Disord Drug Targets 2020; 20(3): 348-9.
[http://dx.doi.org/10.2174/22123989MTA2nMzg9x] [PMID: 32370727]
[21]
Annweiler C, Cao Z, Sabatier JM. Point of view: Should COVID-19 patients be supplemented with vitamin D? Maturitas 2020; 140: 24-6.
[http://dx.doi.org/10.1016/j.maturitas.2020.06.003] [PMID: 32972631]
[22]
Annweiler C, Hanotte B, Grandin de l’Eprevier C, Sabatier JM, Lafaie L, Célarier T. Vitamin D and survival in COVID-19 patients: A quasi-experimental study. J Steroid Biochem Mol Biol 2020; 204: 105771.
[http://dx.doi.org/10.1016/j.jsbmb.2020.105771] [PMID: 33065275]

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