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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Mini-Review Article

Should the Quality of Glycemic Control Guide Dental Implant Therapy in Patients with Diabetes? Focus on Implant Survival

Author(s): Dalia Nourah, Salwa Aldahlawi* and Sebastiano Andreana

Volume 18, Issue 4, 2022

Published on: 06 August, 2021

Article ID: e060821195367 Pages: 8

DOI: 10.2174/1573399817666210806120300

Price: $65

Abstract

Introduction: Optimal glycemic control is crucial to dental implant long-term functional and esthetic success. Despite HbA1c levels of 7% or lower used is as an indicator for good glycemic control, however, this level may not be attainable for all diabetic patients. Most dentists do not consider patients with poor glycemic control candidates for implant therapy due to higher implant failure, infection or other complications.

Aim: This review challenges the concept of one size fits all and aims to critically appraise the evidence for the success or failure rate of dental implants and peri-implant health outcomes in patients with less than optimal glycemic control.

Discussion: Evidence suggests that estimating glycemic control from HbA1c measurement alone is misleading. Moreover, elevated preoperative HbA1c was not associated with increased mortality and morbidity after major surgical procedures. Literature for the survival or success of implants in diabetic patients is inconsistent due to a lack of standardized reporting of clinical data collection and outcomes. While a number of studies report that implant treatment in patients with well controlled diabetes has a similar success rate to healthy individuals, other studies suggest that the quality of glycemic control in diabetic patients does not make a difference in the implant failure rate or marginal bone loss. This discrepancy could indicate that risk factors other than hyperglycemia may contribute to the survival of implants in diabetic patients.

Conclusion: In the era of personalized medicine, the clinician should utilize individualized information and analyze all risk factors to provide the patient with evidence-based treatment options.

Keywords: Dental implant, diabetes, glycemic control, osseointegration, implant success, implant survival.

[1]
Schmidt AM. Diabetes mellitus and cardiovascular disease: Emerging therapeutic approaches. Arterioscler Thromb Vasc Biol 2019; 39(4): 558-68.
[http://dx.doi.org/10.1161/ATVBAHA.119.310961] [PMID: 30786741]
[2]
Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract 2019; 157: 107843.
[http://dx.doi.org/10.1016/j.diabres.2019.107843] [PMID: 31518657]
[3]
Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 2018; 14(2): 88-98.
[http://dx.doi.org/10.1038/nrendo.2017.151] [PMID: 29219149]
[4]
Williams R, Karuranga S, Malanda B, et al. Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract 2020; 162: 108072.
[http://dx.doi.org/10.1016/j.diabres.2020.108072] [PMID: 32061820]
[5]
Beagley J, Guariguata L, Weil C, Motala AA. Global estimates of undiagnosed diabetes in adults. Diabetes Res Clin Pract 2014; 103(2): 150-60.
[http://dx.doi.org/10.1016/j.diabres.2013.11.001] [PMID: 24300018]
[6]
Seitz MW, Listl S, Bartols A, et al. Current knowledge on correlations between highly prevalent dental conditions and chronic diseases: An umbrella review. Prev Chronic Dis 2019; 16: E132.
[http://dx.doi.org/10.5888/pcd16.180641] [PMID: 31560644]
[7]
Luo H, Pan W, Sloan F, Feinglos M, Wu B. Forty-year trends in tooth loss among american adults with and without diabetes mellitus: An age-period-cohort analysis. Prev Chronic Dis 2015; 12: E211.
[http://dx.doi.org/10.5888/pcd12.150309] [PMID: 26632952]
[8]
Meza Maurício J, Miranda TS, Almeida ML, Silva HD, Figueiredo LC, Duarte PM. An umbrella review on the effects of diabetes on implant failure and peri-implant diseases. Braz Oral Res 2019; 33: e070.
[http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0070] [PMID: 31576954]
[9]
de Oliveira-Neto OB, Santos IO, Barbosa FT, de Sousa-Rodrigues CF, de Lima FJ. Quality assessment of systematic reviews regarding dental implant placement on diabetic patients: An overview of systematic reviews. Med Oral Patol Oral Cir Bucal 2019; 24(4): e483-90.
[http://dx.doi.org/10.4317/medoral.22955] [PMID: 31232387]
[10]
Oates TW, Huynh-Ba G. Diabetes effects on dental implant survival. Forum Implantol 2012; 8(2): 7-14.
[PMID: 25328546]
[11]
Javed F, Romanos GE. Impact of diabetes mellitus and glycemic control on the osseointegration of dental implants: A systematic literature review. J Periodontol 2009; 80(11): 1719-30.
[http://dx.doi.org/10.1902/jop.2009.090283] [PMID: 19905942]
[12]
Lagunov VL, Sun J, George R. Evaluation of biologic implant success parameters in type 2 diabetic glycemic control patients versus health patients: A meta-analysis. J Investig Clin Dent 2019; 10(4): e12478.
[http://dx.doi.org/10.1111/jicd.12478] [PMID: 31638347]
[13]
Moraschini V, Barboza ES, Peixoto GA. The impact of diabetes on dental implant failure: A systematic review and meta-analysis. Int J Oral Maxillofac Implants 2016; 45(10): 1237-45.
[http://dx.doi.org/10.1016/j.ijom.2016.05.019] [PMID: 27297836]
[14]
Shi Q, Xu J, Huo N, Cai C, Liu H. Does a higher glycemic level lead to a higher rate of dental implant failure?: A meta-analysis. J Am Dent Assoc 2016; 147(11): 875-81.
[http://dx.doi.org/10.1016/j.adaj.2016.06.011] [PMID: 27435008]
[15]
Shang R, Gao L. Impact of hyperglycemia on the rate of implant failure and peri-implant parameters in patients with type 2 diabetes mellitus: Systematic review and meta-analysis. J Am Dent Assoc 2021; 152(3): 189-201.e1.
[http://dx.doi.org/10.1016/j.adaj.2020.11.015] [PMID: 33632408]
[16]
Altabas V. Diabetes, endothelial dysfunction, and vascular repair: What should a diabetologist keep his eye on? Int J Endocrinol 2015; 2015: 848272.
[http://dx.doi.org/10.1155/2015/848272] [PMID: 26089898]
[17]
Botero JE, Yepes FL, Roldán N, et al. Tooth and periodontal clinical attachment loss are associated with hyperglycemia in patients with diabetes. J Periodontol 2012; 83(10): 1245-50.
[http://dx.doi.org/10.1902/jop.2012.110681] [PMID: 22248217]
[18]
Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 diabetes and its impact on the immune system. Curr Diabetes Rev 2020; 16(5): 442-9.
[http://dx.doi.org/10.2174/1573399815666191024085838] [PMID: 31657690]
[19]
Endara M, Masden D, Goldstein J, Gondek S, Steinberg J, Attinger C. The role of chronic and perioperative glucose management in high-risk surgical closures: A case for tighter glycemic control. Plast Reconstr Surg 2013; 132(4): 996-1004.
[http://dx.doi.org/10.1097/PRS.0b013e31829fe119] [PMID: 23783058]
[20]
World Health O Use of glycated haemoglobin (HbA1c) in diagnosis of diabetes mellitus: abbreviated report of a WHO consultation. Available from: https://apps.who.int/iris/handle/10665/70523
[21]
Khaw K-T, Wareham N. Glycated hemoglobin as a marker of cardiovascular risk. Curr Opin Lipidol 2006; 17(6): 637-43.
[http://dx.doi.org/10.1097/MOL.0b013e3280106b95] [PMID: 17095908]
[22]
Chrcanovic BR, Albrektsson T, Wennerberg A. Diabetes and oral implant failure: A systematic review. J Dent Res 2014; 93(9): 859-67.
[http://dx.doi.org/10.1177/0022034514538820] [PMID: 24928096]
[23]
Naujokat H, Kunzendorf B, Wiltfang J. Dental implants and diabetes mellitus-a systematic review. Int J Implant Dent 2016; 2(1): 5.
[http://dx.doi.org/10.1186/s40729-016-0038-2] [PMID: 27747697]
[24]
Mellado-Valero A, Ferrer García JC, Herrera Ballester A, Labaig Rueda C. Effects of diabetes on the osseointegration of dental implants. Med Oral Patol Oral Cir Bucal 2007; 12(1): E38-43.
[PMID: 17195826]
[25]
Wongdee K, Krishnamra N, Charoenphandhu N. Derangement of calcium metabolism in diabetes mellitus: Negative outcome from the synergy between impaired bone turnover and intestinal calcium absorption. J Physiol Sci 2017; 67(1): 71-81.
[http://dx.doi.org/10.1007/s12576-016-0487-7] [PMID: 27671701]
[26]
Sun DC, Li DH, Ji HC, et al. In vitro culture and characterization of alveolar bone osteoblasts isolated from type 2 diabetics. Braz J Med Biol Res 2012; 45(6): 502-9.
[http://dx.doi.org/10.1590/S0100-879X2012007500054] [PMID: 22473318]
[27]
Xu R, Shi G, Xu L, et al. Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity. J Tissue Eng Regen Med 2018; 12(5): 1209-19.
[http://dx.doi.org/10.1002/term.2652] [PMID: 29498229]
[28]
Zhao Y-F, Zeng D-L, Xia L-G, et al. Osteogenic potential of bone marrow stromal cells derived from streptozotocin-induced diabetic rats. Int J Mol Med 2013; 31(3): 614-20.
[http://dx.doi.org/10.3892/ijmm.2013.1227] [PMID: 23292283]
[29]
Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis. Osteoporos Int 2007; 18(4): 427-44.
[http://dx.doi.org/10.1007/s00198-006-0253-4] [PMID: 17068657]
[30]
Liang C, Sun R, Xu Y, Geng W, Li J. Effect of the abnormal expression of BMP-4 in the blood of diabetic patients on the osteogenic differentiation potential of alveolar BMSCs and the rescue effect of metformin: A bioinformatics-based study. BioMed Res Int 2020; 2020: 7626215.
[http://dx.doi.org/10.1155/2020/7626215] [PMID: 32596370]
[31]
Yu M, Wang H, Fan Z, et al. BMP4 mutations in tooth agenesis and low bone mass. Arch Oral Biol 2019; 103: 40-6.
[http://dx.doi.org/10.1016/j.archoralbio.2019.05.012] [PMID: 31128441]
[32]
Mavropoulos E, Hausen M, Costa AM, et al. The impact of the RGD peptide on osteoblast adhesion and spreading on zinc-substituted hydroxyapatite surface. J Mater Sci Mater Med 2013; 24(5): 1271-83.
[http://dx.doi.org/10.1007/s10856-013-4851-3] [PMID: 23494616]
[33]
Kotsovilis S, Karoussis IK, Fourmousis I. A comprehensive and critical review of dental implant placement in diabetic animals and patients. Clin Oral Implants Res 2006; 17(5): 587-99.
[http://dx.doi.org/10.1111/j.1600-0501.2005.01245.x] [PMID: 16958701]
[34]
Sundar G, Sridharan S, Sundaram RR, Prabhu S, Rao R, Rudresh V. Impact of well-controlled type 2 diabetes mellitus on implant stability and bone biomarkers. Int J Oral Maxillofac Implants 2019; 34(6): 1441-9.
[http://dx.doi.org/10.11607/jomi.7547] [PMID: 31184637]
[35]
Javed F, Romanos GE. Chronic hyperglycemia as a risk factor in implant therapy. Periodontol 2000 2019; 81(1): 57-63.
[http://dx.doi.org/10.1111/prd.12283] [PMID: 31407442]
[36]
Cornier M-A, Dabelea D, Hernandez TL, et al. The metabolic syndrome. Endocr Rev 2008; 29(7): 777-822.
[http://dx.doi.org/10.1210/er.2008-0024] [PMID: 18971485]
[37]
Coelho PG, Pippenger B, Tovar N, et al. Effect of obesity or metabolic syndrome and diabetes on osseointegration of dental implants in a miniature swine model: A pilot study. J Oral Maxillofac Surg 2018; 76(8): 1677-87.
[http://dx.doi.org/10.1016/j.joms.2018.02.021] [PMID: 29572133]
[38]
King S, Baptiston Tanaka C, Ross D, et al. A diet high in fat and fructose adversely affects osseointegration of titanium implants in rats. Clin Exp Dent Res 2020; 6(1): 107-16.
[http://dx.doi.org/10.1002/cre2.255] [PMID: 32067396]
[39]
Underwood P, Askari R, Hurwitz S, Chamarthi B, Garg R. Preoperative A1C and clinical outcomes in patients with diabetes undergoing major noncardiac surgical procedures. Diabetes Care 2014; 37(3): 611-6.
[http://dx.doi.org/10.2337/dc13-1929] [PMID: 24170760]
[40]
Millar K, Cummings M, Cranston I. Perioperative diabetes: The challenges and strategies for glycaemic control management. Pract Diabetes 2019; 36(6): 207-11.
[http://dx.doi.org/10.1002/pdi.2247]
[41]
Yong PH, Weinberg L, Torkamani N, et al. The presence of diabetes and higher HbA1c are independently associated with adverse outcomes after surgery. Diabetes Care 2018; 41(6): 1172-9.
[http://dx.doi.org/10.2337/dc17-2304] [PMID: 29581095]
[42]
Rollins KE, Varadhan KK, Dhatariya K, Lobo DN. Systematic review of the impact of HbA1c on outcomes following surgery in patients with diabetes mellitus. Clin Nutr 2016; 35(2): 308-16.
[http://dx.doi.org/10.1016/j.clnu.2015.03.007] [PMID: 25840840]
[43]
Jiang X, Zhu Y, Liu Z, Tian Z, Zhu S. Association between diabetes and dental implant complications: A systematic review and meta-analysis. Acta Odontol Scand 2021; 79(1): 9-18.
[http://dx.doi.org/10.1080/00016357.2020.1761031] [PMID: 32401121]
[44]
Al Zahrani S, Al Mutairi AA. Crestal bone loss around submerged and non-submerged dental implants in individuals with type-2 diabetes mellitus: A 7-year prospective clinical study. Med Princ Pract 2019; 28(1): 75-81.
[http://dx.doi.org/10.1159/000495111] [PMID: 30396170]
[45]
Oates TW Jr, Galloway P, Alexander P, et al. The effects of elevated hemoglobin A(1c) in patients with type 2 diabetes mellitus on dental implants: Survival and stability at one year. J Am Dent Assoc 2014; 145(12): 1218-26.
[http://dx.doi.org/10.14219/jada.2014.93] [PMID: 25429035]
[46]
Ghiraldini B, Conte A, Casarin RC, et al. Influence of glycemic control on peri-implant bone healing: 12-Month outcomes of local release of bone-related factors and implant stabilization in type 2 diabetics. Clin Implant Dent Relat Res 2016; 18(4): 801-9.
[http://dx.doi.org/10.1111/cid.12339] [PMID: 25825337]
[47]
Olson JW, Shernoff AF, Tarlow JL, Colwell JA, Scheetz JP, Bingham SF. Dental endosseous implant assessments in a type 2 diabetic population: A prospective study. Int J Oral Maxillofac Implants 2000; 15(6): 811-8. PMID: 11151579
[48]
Tawil G, Younan R, Azar P, Sleilati G. Conventional and advanced implant treatment in the type II diabetic patient: Surgical protocol and long-term clinical results. Int J Oral Maxillofac Implants 2008; 23(4): 744-52.
[PMID: 18807573]
[49]
Moy PK, Medina D, Shetty V, Aghaloo TL. Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants 2005; 20(4): 569-77.
[PMID: 16161741]
[50]
Morris HF, Ochi S, Winkler S. Implant survival in patients with type 2 diabetes: Placement to 36 months. Ann Periodontol 2000; 5(1): 157-65.
[http://dx.doi.org/10.1902/annals.2000.5.1.157] [PMID: 11885176]
[51]
Peled M, Ardekian L, Tagger-Green N, Gutmacher Z, Machtei EE. Dental implants in patients with type 2 diabetes mellitus: A clinical study. Implant Dent 2003; 12(2): 116-22.
[http://dx.doi.org/10.1097/01.ID.0000058307.79029.B1] [PMID: 12861878]
[52]
Fiorellini JP, Nevins ML. Dental implant considerations in the diabetic patient. Periodontol 2000 2000; 23(1): 73-7.
[http://dx.doi.org/10.1034/j.1600-0757.2000.2230106.x] [PMID: 11276767]
[53]
Gómez-Moreno G, Aguilar-Salvatierra A, Rubio Roldán J, Guardia J, Gargallo J, Calvo-Guirado JL. Peri-implant evaluation in type 2 diabetes mellitus patients: A 3-year study. Clin Oral Implants Res 2015; 26(9): 1031-5.
[http://dx.doi.org/10.1111/clr.12391] [PMID: 24684438]
[54]
Al-Sowygh ZH, Ghani SMA, Sergis K, Vohra F, Akram Z. Peri-implant conditions and levels of advanced glycation end products among patients with different glycemic control. Clin Implant Dent Relat Res 2018; 20(3): 345-51.
[http://dx.doi.org/10.1111/cid.12584] [PMID: 29350883]
[55]
Al Amri MD, Kellesarian SV, Al-Kheraif AA, Malmstrom H, Javed F, Romanos GE. Effect of oral hygiene maintenance on HbA1c levels and peri-implant parameters around immediately-loaded dental implants placed in type-2 diabetic patients: 2 years follow-up. Clin Oral Implants Res 2016; 27(11): 1439-43.
[http://dx.doi.org/10.1111/clr.12758] [PMID: 26756309]
[56]
O’Connell PA, Taba M Jr, Nomizo A, et al. Effects of periodontal therapy on glycemic control and inflammatory markers. J Periodontol 2008; 79(5): 774-83.
[http://dx.doi.org/10.1902/jop.2008.070250] [PMID: 18454655]
[57]
Baeza M, Morales A, Cisterna C, et al. Effect of periodontal treatment in patients with periodontitis and diabetes: Systematic review and meta-analysis. J Appl Oral Sci 2020; 28: e20190248.
[http://dx.doi.org/10.1590/1678-7757-2019-0248] [PMID: 31939522]
[58]
Singh M, Bains VK, Jhingran R, et al. Prevalence of periodontal disease in type 2 diabetes mellitus patients: A cross-sectional study. Contemp Clin Dent 2019; 10(2): 349-57.
[PMID: 32308302]
[59]
Sábado-Bundó H, Sánchez-Garcés MÁ, Gay-Escoda C. Bone regeneration in diabetic patients. A systematic review. Med Oral Patol Oral Cir Bucal 2019; 24(4): e425-32.
[http://dx.doi.org/10.4317/medoral.22889] [PMID: 31246936]
[60]
Beck RW, Connor CG, Mullen DM, Wesley DM, Bergenstal RM. The fallacy of average: How using HbA1c alone to assess glycemic control can be misleading. Diabetes Care 2017; 40(8): 994-9.
[http://dx.doi.org/10.2337/dc17-0636] [PMID: 28733374]
[61]
Bergenstal RM, Gal RL, Connor CG, et al. Racial differences in the relationship of glucose concentrations and hemoglobin A1c levels. Ann Intern Med 2017; 167(2): 95-102.
[http://dx.doi.org/10.7326/M16-2596] [PMID: 28605777]
[62]
Kohnert K-D, Heinke P, Vogt L, Salzsieder E. Utility of different glycemic control metrics for optimizing management of diabetes. World J Diabetes 2015; 6(1): 17-29.
[http://dx.doi.org/10.4239/wjd.v6.i1.17] [PMID: 25685275]
[63]
Heller SR, Bergenstal RM, White WB, et al. Relationship of glycated haemoglobin and reported hypoglycaemia to cardiovascular outcomes in patients with type 2 diabetes and recent acute coronary syndrome events: The examine trial. Diabetes Obes Metab 2017; 19(5): 664-71.
[http://dx.doi.org/10.1111/dom.12871] [PMID: 28058763]
[64]
Lee AK, Warren B, Lee CJ, et al. Association of severe hypoglycemia with cardiovascular disease and all-cause mortality in older adults with diabetes: The atherosclerosis risk in communities (ARIC) study. Circulation 2017; 135: A43-3.
[http://dx.doi.org/10.1161/circ.135.suppl_1.p048]
[65]
Sghaireen MG, Alduraywish AA, Srivastava KC, et al. Comparative evaluation of dental implant failure among healthy and well- controlled diabetic patients-a 3-year retrospective study. Int J Environ Res Public Health 2020; 17(14): E5253.
[http://dx.doi.org/10.3390/ijerph17145253] [PMID: 32708165]
[66]
Dubey RK, Gupta DK, Singh AK. Dental implant survival in diabetic patients; review and recommendations. Natl J Maxillofac Surg 2013; 4(2): 142-50.
[http://dx.doi.org/10.4103/0975-5950.127642] [PMID: 24665167]
[67]
Eskow CC, Oates TW. Dental implant survival and complication rate over 2 years for individuals with poorly controlled type 2 diabetes mellitus. Clin Implant Dent Relat Res 2017; 19(3): 423-31.
[http://dx.doi.org/10.1111/cid.12465] [PMID: 27990756]
[68]
Dowell S, Oates TW, Robinson M. Implant success in people with type 2 diabetes mellitus with varying glycemic control: A pilot study. J Am Dent Assoc 2007; 138(3): 355-61.
[http://dx.doi.org/10.14219/jada.archive.2007.0168] [PMID: 17332041]
[69]
Borba AM, Souza DF, Brozoski MA, Burim RA, Naclério-Homem MdaG, Deboni MC. Can the use of antibiotics interfere with the success of dental osseointegrated implants in diabetic patients? J Contemp Dent Pract 2013; 14(6): 1197-201.
[http://dx.doi.org/10.5005/jp-journals-10024-1476] [PMID: 24858776]
[70]
Oates TW, Dowell S, Robinson M, McMahan CA. Glycemic control and implant stabilization in type 2 diabetes mellitus. J Dent Res 2009; 88(4): 367-71.
[http://dx.doi.org/10.1177/0022034509334203] [PMID: 19407159]
[71]
Ormianer Z, Block J, Matalon S, Kohen J. The effect of moderately controlled type 2 diabetes on dental implant survival and peri-implant bone loss: A long-term retrospective study. Int J Oral Maxillofac Implants 2018; 33(2): 389-94.
[http://dx.doi.org/10.11607/jomi.5838] [PMID: 29534127]
[72]
Oates TW, Huynh-Ba G, Vargas A, Alexander P, Feine J. A critical review of diabetes, glycemic control, and dental implant therapy. Clin Oral Implants Res 2013; 24(2): 117-27.
[http://dx.doi.org/10.1111/j.1600-0501.2011.02374.x] [PMID: 22111901]
[73]
Cabrera-Domínguez J, Castellanos-Cosano L, Torres-Lagares D, Machuca-Portillo G. A prospective case-control clinical study of titanium-zirconium alloy implants with a hydrophilic surface in patients with type 2 diabetes mellitus. Int J Oral Maxillofac Implants 2017; 32(5): 1135-44.
[http://dx.doi.org/10.11607/jomi.5577] [PMID: 28906508]
[74]
Al-Shibani N, Al-Aali KA, Al-Hamdan RS, Alrabiah M, Basunbul G, Abduljabbar T. Comparison of clinical peri-implant indices and crestal bone levels around narrow and regular diameter implants placed in diabetic and non-diabetic patients: A 3-year follow-up study. Clin Implant Dent Relat Res 2019; 21(2): 247-52.
[http://dx.doi.org/10.1111/cid.12712] [PMID: 30624014]
[75]
Khandelwal N, Oates TW, Vargas A, Alexander PP, Schoolfield JD, Alex McMahan C. Conventional SLA and chemically modified SLA implants in patients with poorly controlled type 2 diabetes mellitus-a randomized controlled trial. Clin Oral Implants Res 2013; 24(1): 13-9.
[http://dx.doi.org/10.1111/j.1600-0501.2011.02369.x] [PMID: 22145978]
[76]
Singh K, Rao J, Afsheen T, Tiwari B. Survival rate of dental implant placement by conventional or flapless surgery in controlled type 2 diabetes mellitus patients: A systematic review. Indian J Dent Res 2019; 30(4): 600-11.
[http://dx.doi.org/10.4103/ijdr.IJDR_606_17] [PMID: 31745060]
[77]
Souto-Maior JR, Pellizzer EP, de Luna Gomes JM, et al. Influence of diabetes on the survival rate and marginal bone loss of dental implants: An overview of systematic reviews. J Oral Implantol 2019; 45(4): 334-40.
[http://dx.doi.org/10.1563/aaid-joi-D-19-00087] [PMID: 31042455]

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