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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Review Article

Role of MicroRNAs in the Progression and Metastasis of Colon Cancer

Author(s): Shruthi Sanjitha Sampath, Sivaramakrishnan Venkatabalasubramanian and Satish Ramalingam*

Volume 21, Issue 1, 2021

Published on: 25 August, 2020

Page: [35 - 46] Pages: 12

DOI: 10.2174/1871530320666200825184924

Price: $65

Abstract

MicroRNAs regulate gene expression at the posttranscriptional level by binding to the mRNA of their target genes. The dysfunction of miRNAs is strongly associated with the inflammation of the colon. Besides, some microRNAs are shown to suppress tumours, while others promote tumour progression and metastasis. Inflammatory bowel diseases include Crohn’s disease and Ulcerative colitis, which increase the risk factor for inflammation-associated colon cancer. MicroRNAs are shown to be involved in gastrointestinal pathologies by targeting the transcripts encoding proteins of the intestinal barrier and their regulators that are associated with inflammation and colon cancer. Detection of these microRNAs in the blood, serum, tissues, faecal matter, etc, will enable us to use these microRNAs as biomarkers for early detection of the associated malignancies and design novel therapeutic strategies to overcome the same. Information on MicroRNAs can be applied for the development of targeted therapies against inflammation-mediated colon cancer.

Keywords: MicroRNA, ulcerative colitis, colon cancer, Crohn's disease, metastasis, biomarkers.

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