Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
General Research Article

Efficacy of Fluorescence Technology vs Conventional Oral Examination for the Early Detection of Oral Pre-Malignant Lesions. A Clinical Comparative Study

Author(s): Rajiv Saini, Stefania Cantore, Sugandha R. Saini, Filiberto Mastrangelo, Andrea Ballini and Luigi Santacroce*

Volume 19, Issue 6, 2019

Page: [852 - 858] Pages: 7

DOI: 10.2174/1871530319666190119103255

Price: $65

Abstract

Background and Objective: Oral cancer is one of the most common malignancies that affect human beings across the world and early detection of oral cancer is believed to reduce the morbidity significantly. Fluorescence diagnosis is emerging as a promising method in the differentiation of cancerous lesions and thus helping in the determination of resolution for the surgical resection of affected area of malignancy very accurately. The aim of this study was to evaluate the usefulness of an autofluorescence hand held device (OralID) to detect oral premalignant lesions.

Methods: 98 potentially high-risk oral cancer patients were divided into two groups (n=49/group). Both the groups were first examined by conventional oral examination under white light and oral findings were noted. Subjects under group B were further examined under fluorescence light through hand held device, i.e. OralID. After the examinations, a surgical biopsy sample was taken from the suspected lesions under local anaesthesia from both the groups to confirm the diagnosis through histopathological analysis.

Results: The positive potential malignant lesions (PMLs) observed in Group A when compared with biopsy reporting was 89.47% true positive while in Group B was 95.24%. The sensitivity reported of Group A was 89.47% and Group B was 97.56%. We observed 8.09% more sensitivity and 11.36% more specificity when we incorporate adjunctive the fluorescence examination using OralID.

Conclusion: Results from this study suggests that OralID is a true adjunct to conventional oral examination in detecting early potential malignant changes in subjects visiting for regular dental check-up.

Keywords: OralID, oral cancer, erythroplakia, leukoplakia, pre-neoplastic lesions, non-invasive diagnosis.

« Previous Next »
Graphical Abstract

[1]
Sudhakar, A. History of Cancer, Ancient and Modern Treatment Methods. J. Cancer Sci. Ther., 2009, 1(2), 1-4.
[http://dx.doi.org/10.4172/1948-5956.100000e2] [PMID: 20740081]
[2]
Pannone, G.; Lo Muzio, L.; Bucci, P.; Canfora, M.; Pannone, G.; Santacroce, L.; Bucci, T.; Staibano, S. [Physiopathology of beta and gamma catenin expression in the oral epithelium] Minerva Stomatol., 1998, 47(11), 583-588.
[PMID: 9882993]
[3]
Ballini, A.; Scattarella, A.; Crincoli, V.; Carlaio, R.G.; Papa, F.; Perillo, L.; Romanazzo, T.; Bux, M.V.; Nardi, G.M.; Dituri, A.; Cantore, S.; Pettini, F.; Grassi, F.R. Surgical treatment of gingival overgrowth with 10 years of follow-up. Head Face Med., 2010, 6, 19.
[http://dx.doi.org/10.1186/1746-160X-6-19] [PMID: 20704737]
[4]
Sankaranarayanan, R.; Black, R.J.; Swaminathan, R.; Parkin, D.M. An overview of cancer survival in developing countries. IARC Sci. Publ., 1998, (145), 135-173.
[PMID: 10194635]
[5]
Marzullo, A.; Serio, G.; Madami, L.; Pezzuto, F.; Fortarezza, F.; Quaranta, N.; Fiorella, M.L.; Lettini, T.; Resta, L.; Marrelli, M.; Tatullo, M.; Santacroce, L. Intraoperative frozen section as a reliable ancillary technique in salivary gland surgery: A cross sectional study. F1000 Res., 2018, 7, 231.
[http://dx.doi.org/10.12688/f1000research.13043.1]
[6]
Li, Y.; Elashoff, D.; Oh, M.; Sinha, U.; St John, M.A.; Zhou, X.; Abemayor, E.; Wong, D.T. Serum circulating human mRNA profiling and its utility for oral cancer detection. J. Clin. Oncol., 2006, 24(11), 1754-1760.
[http://dx.doi.org/10.1200/JCO.2005.03.7598] [PMID: 16505414]
[7]
Noonan, V.L.; Kabani, S. Diagnosis and management of suspicious lesions of the oral cavity. Otolaryngol. Clin. North Am., 2005, 38(1), 21-35. vii
[http://dx.doi.org/10.1016/j.otc.2004.09.008] [PMID: 15649496]
[8]
Roblyer, D.; Richards-Kortum, R. Optical diagnostics for early detection of oral cancer. Access, 2010, 24, 22-25.
[9]
Gupta, P.C.; Bhonsle, R.B.; Murty, P.R.; Mehta, F.S.; Pindborg, J.J. Epidemiologic characteristics of treated oral cancer patients detected in a house-to-house survey in Kerala, India. Indian J. Cancer, 1986, 23(4), 206-211.
[PMID: 3653921]
[10]
Zavras, A.I.; Douglass, C.W.; Joshipura, K.; Wu, T.; Laskaris, G.; Petridou, E.; Dokianakis, G.; Segas, J.; Lefantzis, D.; Nomikos, P.; Wang, Y.F.; Diehl, S.R. Smoking and alcohol in the etiology of oral cancer: gender-specific risk profiles in the south of Greece. Oral Oncol., 2001, 37(1), 28-35.
[http://dx.doi.org/10.1016/S1368-8375(00)00060-9] [PMID: 11120480]
[11]
Warnakulasuriya, S.; Johnson, N.W.; van der Waal, I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J. Oral Pathol. Med., 2007, 36(10), 575-580.
[http://dx.doi.org/10.1111/j.1600-0714.2007.00582.x] [PMID: 17944749]
[12]
Rethman, M.P.; Carpenter, W.; Cohen, E.E.; Epstein, J.; Evans, C.A.; Flaitz, C.M.; Graham, F.J.; Hujoel, P.P.; Kalmar, J.R.; Koch, W.M.; Lambert, P.M.; Lingen, M.W.; Oettmeier, B.W., Jr; Patton, L.L.; Perkins, D.; Reid, B.C.; Sciubba, J.J.; Tomar, S.L.; Wyatt, A.D., Jr; Aravamudhan, K.; Frantsve-Hawley, J.; Cleveland, J.L.; Meyer, D.M. American Dental Association Council on Scientific Affairs Expert Panel on Screening for Oral Squamous Cell Carcinomas. Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas. J. Am. Dent. Assoc., 2010, 141(5), 509-520.
[http://dx.doi.org/10.14219/jada.archive.2010.0223] [PMID: 20436098]
[13]
McCullough, M.J.; Prasad, G.; Farah, C.S. Oral mucosal malignancy and potentially malignant lesions: an update on the epidemiology, risk factors, diagnosis and management. Aust. Dent. J., 2010, 55(Suppl. 1), 61-65.
[http://dx.doi.org/10.1111/j.1834-7819.2010.01200.x] [PMID: 20553246]
[14]
Downer, M.C.; Moles, D.R.; Palmer, S.; Speight, P.M. A systematic review of test performance in screening for oral cancer and precancer. Oral Oncol., 2004, 40(3), 264-273.
[http://dx.doi.org/10.1016/j.oraloncology.2003.08.013] [PMID: 14747057]
[15]
Balasubramaniam, A.M.; Sriraman, R.; Sindhuja, P.; Mohideen, K.; Parameswar, R.A.; Muhamed Haris, K.T. Autofluorescence based diagnostic techniques for oral cancer. J. Pharm. Bioallied Sci., 2015, 7(Suppl. 2), S374-S377.
[http://dx.doi.org/10.4103/0975-7406.163456] [PMID: 26538880]
[16]
De Stefani, E.; Boffetta, P.; Deneo-Pellegrini, H.; Ronco, A.L.; Acosta, G.; Ferro, G.; Oreggia, F.; Leiva, J. The effect of smoking and drinking in oral and pharyngeal cancers: a case-control study in Uruguay. Cancer Lett., 2007, 246(1-2), 282-289.
[http://dx.doi.org/10.1016/j.canlet.2006.03.008] [PMID: 16624486]
[17]
Moreno-López, L.A.; Esparza-Gómez, G.C.; González-Navarro, A.; Cerero-Lapiedra, R.; González-Hernández, M.J.; Domínguez-Rojas, V. Risk of oral cancer associated with tobacco smoking, alcohol consumption and oral hygiene: a case-control study in Madrid, Spain. Oral Oncol., 2000, 36(2), 170-174.
[http://dx.doi.org/10.1016/S1368-8375(99)00084-6] [PMID: 10745168]
[18]
Adil, H.A.; Yuwanati, M.; Singh, A.; Sawant, S.; Umarji, H.R. Comparative study on the efficacy of tissue autofluorescence (visually enhanced lesion scope) and toluidine blue as a screening method in oral potentially malignant and malignant lesions. J. Med. Sci, 2017, 37, 91-96.
[19]
Rahman, M.S.; Ingole, N.; Roblyer, D.; Stepanek, V.; Richards-Kortum, R.; Gillenwater, A.; Shastri, S.; Chaturvedi, P. Evaluation of a low-cost, portable imaging system for early detection of oral cancer. Head Neck Oncol., 2010, 2, 10.
[http://dx.doi.org/10.1186/1758-3284-2-10] [PMID: 20409347]
[20]
Svistun, E.; Alizadeh-Naderi, R.; El-Naggar, A.; Jacob, R.; Gillenwater, A.; Richards-Kortum, R. Vision enhancement system for detection of oral cavity neoplasia based on autofluorescence. Head Neck, 2004, 26(3), 205-215.
[http://dx.doi.org/10.1002/hed.10381] [PMID: 14999795]
[21]
Awan, K.H.; Morgan, P.R.; Warnakulasuriya, S. Evaluation of an autofluorescence based imaging system (VELscope™) in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncol., 2011, 47(4), 274-277.
[http://dx.doi.org/10.1016/j.oraloncology.2011.02.001] [PMID: 21396880]
[22]
Onizawa, K.; Saginoya, H.; Furuya, Y.; Yoshida, H.; Fukuda, H. Usefulness of fluorescence photography for diagnosis of oral cancer. Int. J. Oral Maxillofac. Surg., 1999, 28(3), 206-210.
[http://dx.doi.org/10.1016/S0901-5027(99)80140-4] [PMID: 10355944]
[23]
Kulapaditharom, B.; Boonkitticharoen, V. Performance characteristics of fluorescence endoscope in detection of head and neck cancers. Ann. Otol. Rhinol. Laryngol., 2001, 110(1), 45-52.
[http://dx.doi.org/10.1177/000348940111000109] [PMID: 11201808]
[24]
Saini, R. Oral Cancer Screening in Dental Set Up. Int. J. Biol. Adv. Res., 2015, 6, 199-203.
[http://dx.doi.org/10.7439/ijbar.v6i3.1829]
[25]
Tatullo, M.; Marrelli, M.; Amantea, M.; Paduano, F.; Santacroce, L.; Gentile, S.; Scacco, S. Bioimpedance Detection of Oral Lichen Planus Used as Preneoplastic Model. J. Cancer, 2015, 6(10), 976-983.
[http://dx.doi.org/10.7150/jca.11936] [PMID: 26366210]
[26]
Tatullo, M.; Gentile, S.; Paduano, F.; Santacroce, L.; Marrelli, M. Crosstalk between oral and general health status in e-smokers. Medicine (Baltimore), 2016, 95(49)e5589
[http://dx.doi.org/10.1097/MD.0000000000005589] [PMID: 27930577]
[27]
Santacroce, L.; Luperto, P.; Fiorella, M.L.; Losacco, T. [Carcinoma of unknown origin++ with latero-cervical metastasis. Diagnostic problems. Retrospective analysis of 110 cases of latero-cervical tumefaction] Clin. Ter., 2000, 151(3), 199-201.
[PMID: 10958056]
[28]
Vermesan, D.; Vermesan, H.; Dragulescu, S.I.; Bera, I.; Di Giovanni, A.; Sabatini, R.; Santacroce, L.; Bottalico, L.; Flace, P.; Cagiano, R. Secondary pathologic fractures in osteosarcoma: prognosis and evolution. Eur. Rev. Med. Pharmacol. Sci., 2009, 13(2), 71-76.
[PMID: 19499840]
[29]
Santacroce, L.; Errico, E.; Santacroce, S. Laterocervical swelling as first sign of tumor. J. Chemother., 1997, 9(2), 127-128.
[http://dx.doi.org/10.1179/joc.1997.9.2.127] [PMID: 9176756]
[30]
Lovreglio, P.; Bukvic, N.; Fustinoni, S.; Ballini, A.; Drago, I.; Foà, V.; Guanti, G.; Soleo, L. Lack of genotoxic effect in workers exposed to very low doses of 1,3-butadiene. Arch. Toxicol., 2006, 80(6), 378-381.
[http://dx.doi.org/10.1007/s00204-005-0046-0] [PMID: 16307232]
[31]
Mori, G.; Brunetti, G.; Colucci, S.; Oranger, A.; Ciccolella, F.; Sardone, F.; Pignataro, P.; Mori, C.; Karapanou, V.; Ballini, A.; Mastrangelo, F.; Tete, S.; Grassi, F.R.; Grano, M. Osteoblast apoptosis in periodontal disease: role of TNF-related apoptosis-inducing ligand. Int. J. Immunopathol. Pharmacol., 2009, 22(1), 95-103.
[http://dx.doi.org/10.1177/039463200902200111] [PMID: 19309556]
[32]
Giudice, G.; Cutrignelli, D.A.; Sportelli, P.; Limongelli, L.; Tempesta, A.; Gioia, G.D.; Santacroce, L.; Maiorano, E.; Favia, G. Rhinocerebral Mucormycosis with Orosinusal Involvement: Diagnostic and Surgical Treatment Guidelines. Endocr. Metab. Immune Disord. Drug Targets, 2016, 16(4), 264-269.
[http://dx.doi.org/10.2174/1871530316666161223145055] [PMID: 28017141]
[33]
Bottalico, L.; Tatullo, M.; Marrelli, M.; Santacroce, L. Lights and shadows of dental implants: focus on mucositis and perimplantitis and their biological markers. J. Biol. Regul. Homeost. Agents, 2016, 30(3), 859-861.
[PMID: 27655511]
[34]
Santacroce, L.; D’agostino, D.; Charitos, I.A.; Bottalico, L.; Ballini, A. A short review about electrophysiology and bioimpedance: History and perspectives. Indian J. Public Health Dev., 2018, 9(11), 587-591.
[http://dx.doi.org/10.5958/0976-5506.2018.01521.8]

Rights & Permissions Print Cite
Article Metrics
78
6
1
1
© 2024 Bentham Science Publishers | Privacy Policy