Abstract
Background: Relatively little cancer genome atlas data has been associated with clinically relevant stratifications of individual cancers.
Results: Mutations in two subsets of a cytoskeletal related and adhesion-related protein coding region set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma, including a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001). Conclusion: Roles for CAPCR mutations in cancer progression raise a question about the potential dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein structures.Keywords: Cytoskeletal and cell-adhesion genomics, Cancer genome atlas, Extra-cellular matrix, Melanoma stratification, Melanoma metastasis.
Current Genomics
Title:Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome
Volume: 18 Issue: 3
Author(s): John M. Yavorski, Rebecca J. Stoll, Mohammad D. Samy, James A. Mauro and George Blanck*
Affiliation:
- Department of Molecular Medicine, Morsani College of Medicine, University of South Florida,United States
Keywords: Cytoskeletal and cell-adhesion genomics, Cancer genome atlas, Extra-cellular matrix, Melanoma stratification, Melanoma metastasis.
Abstract: Background: Relatively little cancer genome atlas data has been associated with clinically relevant stratifications of individual cancers.
Results: Mutations in two subsets of a cytoskeletal related and adhesion-related protein coding region set (CAPCRs) were determined to have strong associations with a negative outcome for melanoma, including a subset constituted by: DSCAM, FAT3, MUC17 and PCDHGC5 (p < 0.0001). Conclusion: Roles for CAPCR mutations in cancer progression raise a question about the potential dominant negative impact of these mutations for multi-meric subcellular and extra-cellular protein structures.Export Options
About this article
Cite this article as:
Yavorski M. John, Stoll J. Rebecca, Samy D. Mohammad, Mauro A. James and Blanck George*, Identification of Sets of Cytoskeletal Related and Adhesion-related Coding Region Mutations in the TCGA Melanoma Dataset that Correlate with a Negative Outcome, Current Genomics 2017; 18 (3) . https://dx.doi.org/10.2174/1389202918666170105093953
DOI https://dx.doi.org/10.2174/1389202918666170105093953 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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