Abstract
Telomerase activation is a hallmark of cancer. Telomerase is a specialized ribonucleoprotein complex that uses its RNA subunit to synthesize the repetitive G-rich DNA found at the 3 ends of chromosomes (Telomere). Most cancer cells upregulates telomerase to attain cellular immortalization and cell regulation, whereas, telomerase in normal human somatic cells have a limited proliferative capacity both In-vitro and In-vivo and undergo senescence. Due to the differential expression pattern of telomerase between normal and tumor cells, telomerase has received significant attention as a universal cancer target. Additionally, since telomerase is expressed in stem cells during all stages of life, it has been linked to the process of aging and age-related diseases. Despite the great interest in telomerase, current understanding of telomerase and its regulation remains limited.
Keywords: Aging, cancer, G-quadruplex, senescence, telomerase inhibitor, telomerase.
Mini-Reviews in Organic Chemistry
Title:Telomerase Inhibitors: Potential Anticancer Agents
Volume: 13 Issue: 1
Author(s): Rakesh R. Somani and Mayuri H. Patel
Affiliation:
Keywords: Aging, cancer, G-quadruplex, senescence, telomerase inhibitor, telomerase.
Abstract: Telomerase activation is a hallmark of cancer. Telomerase is a specialized ribonucleoprotein complex that uses its RNA subunit to synthesize the repetitive G-rich DNA found at the 3 ends of chromosomes (Telomere). Most cancer cells upregulates telomerase to attain cellular immortalization and cell regulation, whereas, telomerase in normal human somatic cells have a limited proliferative capacity both In-vitro and In-vivo and undergo senescence. Due to the differential expression pattern of telomerase between normal and tumor cells, telomerase has received significant attention as a universal cancer target. Additionally, since telomerase is expressed in stem cells during all stages of life, it has been linked to the process of aging and age-related diseases. Despite the great interest in telomerase, current understanding of telomerase and its regulation remains limited.
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Cite this article as:
R. Somani Rakesh and H. Patel Mayuri, Telomerase Inhibitors: Potential Anticancer Agents, Mini-Reviews in Organic Chemistry 2016; 13 (1) . https://dx.doi.org/10.2174/1570193X13666160225000624
DOI https://dx.doi.org/10.2174/1570193X13666160225000624 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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