Abstract
Nanogel nanoparticles loaded with active compounds are referred to as Drug-loaded polymeric colloidal nanogels (DPCNs). These nanogels are emerging as promising carriers for transdermal drug delivery applications. Much interest has been directed towards the potential use of DPCNs to deliver a variety of drugs for either controlled or sustained drug delivery systems. Transdermal drug delivery systems (TDDS) have shown a number of beneficial properties such as improving patients compliance as they are conveniently dosed compared to intravenous and oral therapy. The use of TDDS depends on the effectiveness of the drug formulation to accumulate in sufficient concentrations at the specific targeted sites, hence the therapeutic significance of DPCNs in TDDS. Nanogels have a high drug loading capacity, biodegradability and biocompatibility, which are the key points in designing an efficient TDDS. The advanced development of DPCN has led to stimuli responsive drug delivery systems that release the entrapped drug under variable environmental incentives. The development of these drug delivery systems has created room for further research to characterize the physical and chemical properties of theses nanogels as well as their in vitro and in vivo behavior. Therefore this review presents an insight on the basic fabrication methods, advanced developments, limitations and therapeutic significance of the DPCN in TDDS as well as forthcoming potential applications. Despite these numerous positive scientific findings, efficient TDDS remains a challenge for pharmaceutical scientists and significant amount of research is still directed toward the development of superior TDDS.
Keywords: Advanced developments, drug-loaded polymeric colloidal nanogels, stimuli responsive drug delivery systems, transdermal drug delivery systems.
Current Pharmaceutical Design
Title:A Review of Polymeric Colloidal Nanogels in Transdermal Drug Delivery
Volume: 21 Issue: 20
Author(s): Simphiwe Mavuso, Thashree Marimuthu, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit and Viness Pillay
Affiliation:
Keywords: Advanced developments, drug-loaded polymeric colloidal nanogels, stimuli responsive drug delivery systems, transdermal drug delivery systems.
Abstract: Nanogel nanoparticles loaded with active compounds are referred to as Drug-loaded polymeric colloidal nanogels (DPCNs). These nanogels are emerging as promising carriers for transdermal drug delivery applications. Much interest has been directed towards the potential use of DPCNs to deliver a variety of drugs for either controlled or sustained drug delivery systems. Transdermal drug delivery systems (TDDS) have shown a number of beneficial properties such as improving patients compliance as they are conveniently dosed compared to intravenous and oral therapy. The use of TDDS depends on the effectiveness of the drug formulation to accumulate in sufficient concentrations at the specific targeted sites, hence the therapeutic significance of DPCNs in TDDS. Nanogels have a high drug loading capacity, biodegradability and biocompatibility, which are the key points in designing an efficient TDDS. The advanced development of DPCN has led to stimuli responsive drug delivery systems that release the entrapped drug under variable environmental incentives. The development of these drug delivery systems has created room for further research to characterize the physical and chemical properties of theses nanogels as well as their in vitro and in vivo behavior. Therefore this review presents an insight on the basic fabrication methods, advanced developments, limitations and therapeutic significance of the DPCN in TDDS as well as forthcoming potential applications. Despite these numerous positive scientific findings, efficient TDDS remains a challenge for pharmaceutical scientists and significant amount of research is still directed toward the development of superior TDDS.
Export Options
About this article
Cite this article as:
Mavuso Simphiwe, Marimuthu Thashree, Choonara E. Yahya, Kumar Pradeep, du Toit C. Lisa and Pillay Viness, A Review of Polymeric Colloidal Nanogels in Transdermal Drug Delivery, Current Pharmaceutical Design 2015; 21 (20) . https://dx.doi.org/10.2174/1381612821666150428142920
DOI https://dx.doi.org/10.2174/1381612821666150428142920 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Activin Receptor-Like Kinases: Structure, Function and Clinical Implications
Endocrine, Metabolic & Immune Disorders - Drug Targets Recent Innovations in Antibody-Mediated, Targeted Particulate Nanotechnology and Implications for Advanced Visualisation and Drug Delivery
Current Nanoscience Insights into Targeting Colon Cancer Cell Fate at the Level of Proteoglycans / Glycosaminoglycans
Current Medicinal Chemistry PET Studies on P-Glycoprotein Function in the Blood-Brain Barrier: How it Affects Uptake and Binding of Drugs within the CNS
Current Pharmaceutical Design 5-Aminoisoquinolin-1-one (5-AIQ), a Water-Soluble Inhibitor of the Poly(ADP-Ribose)Polymerases (PARPs)
Current Medicinal Chemistry Notch Signalling Pathways and Their Importance in the Treatment of Cancers
Current Drug Targets Novel Drug Delivery System for Cancer Management: A Review
Current Cancer Therapy Reviews Targeting Telomerase for Cancer Therapy
Current Cancer Therapy Reviews Cancer Therapy By Targeting Hypoxia-Inducible Factor-1
Current Cancer Drug Targets Applications of HPLC-MALDI-TOF MS/MS Phosphoproteomic Analysis in Oncological Clinical Diagnostics
Current Proteomics Pharmacological Inhibition of the Bcl-2 Family of Apoptosis Regulators as Cancer Therapy
Current Molecular Pharmacology Induced Pluripotent Stem Cells (iPSCs) Derived from Different Cell Sources and their Potential for Regenerative and Personalized Medicine
Current Molecular Medicine The Role of T-Helper Cells in Atherosclerosis
Cardiovascular & Hematological Agents in Medicinal Chemistry Zoledronic Acid: Pleiotropic Anti-Tumor Mechanism and Therapeutic Outlook for Osteosarcoma
Current Drug Targets The Synergistic Effect of Humanized Monoclonal Antibodies Targeting Insulin-Like Growth Factor 1 Receptor (IGF-1R) and Chemotherapy
Current Drug Targets Development of Therapeutics for High Grade Gliomas Using Orthotopic Rodent Models
Current Medicinal Chemistry Recent Clinical Experience with Oncolytic Viruses
Current Pharmaceutical Biotechnology The Mechanism of Calcitriol in Cancer Prevention and Treatment
Current Medicinal Chemistry A hypothesis for the role of RECK in angiogenesis
Current Vascular Pharmacology The Role of P2X Receptors in Bone Biology
Current Medicinal Chemistry