Abstract
A flow-based system with solenoid micro-pumps is proposed for fast simvastatin (SMT) determination in pharmaceutical preparations. The method is based on the inhibition of methyl orange bromination in the presence of the analyte with spectrophotometric detection. A linear response was observed between 5.0 and 35 mg L-1 SMT with a detection limit of 1.2 mg L-1 (99.7% confidence level). The coefficient of variation (n = 20) and sampling rate were estimated as 3.3% and 80 determinations per hour, respectively. Reagents consumption was estimated as 3.5 μg of NaBrO3, 9.5 μg of methyl orange and 400 μg of NaBr per determination, generating 4.5 mL of waste. The results for pharmaceutical samples agreed with those obtained by the reference chromatographic procedure at the 95% confidence level. The procedure is a fast, greener and reliable alternative for SMT determination.
Keywords: Simvastatin, Flow analysis, Multicommutation, Multi-pumping, Spectrophotometry, SMT, pharmaceutical, Vascular diseases, chromatographic, Mechanization
Current Pharmaceutical Analysis
Title:A Multi-pumping Flow System for Fast Spectrophotometric Determination of Simvastatin
Volume: 9 Issue: 1
Author(s): Wanessa R. Melchert, Alex D. Batista, Andreia C. Pereira, Diogo L. Rocha and Fabio R.P. Rocha
Affiliation:
Keywords: Simvastatin, Flow analysis, Multicommutation, Multi-pumping, Spectrophotometry, SMT, pharmaceutical, Vascular diseases, chromatographic, Mechanization
Abstract: A flow-based system with solenoid micro-pumps is proposed for fast simvastatin (SMT) determination in pharmaceutical preparations. The method is based on the inhibition of methyl orange bromination in the presence of the analyte with spectrophotometric detection. A linear response was observed between 5.0 and 35 mg L-1 SMT with a detection limit of 1.2 mg L-1 (99.7% confidence level). The coefficient of variation (n = 20) and sampling rate were estimated as 3.3% and 80 determinations per hour, respectively. Reagents consumption was estimated as 3.5 μg of NaBrO3, 9.5 μg of methyl orange and 400 μg of NaBr per determination, generating 4.5 mL of waste. The results for pharmaceutical samples agreed with those obtained by the reference chromatographic procedure at the 95% confidence level. The procedure is a fast, greener and reliable alternative for SMT determination.
Export Options
About this article
Cite this article as:
R. Melchert Wanessa, D. Batista Alex, C. Pereira Andreia, L. Rocha Diogo and R.P. Rocha Fabio, A Multi-pumping Flow System for Fast Spectrophotometric Determination of Simvastatin, Current Pharmaceutical Analysis 2013; 9 (1) . https://dx.doi.org/10.2174/1573412911309010015
DOI https://dx.doi.org/10.2174/1573412911309010015 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimers Disease
Current Neuropharmacology Pharmacokinetic and Pharmacodynamic Properties of Anti-VEGF Drugs After Intravitreal Injection
Current Drug Metabolism Large Artery Stiffness and Antihypertensive Agents
Current Pharmaceutical Design Are the Pleiotropic Effects of Telmisartan Clinically Relevant?
Current Pharmaceutical Design Radiation-Induced Extracranial Carotid Stenosis
Vascular Disease Prevention (Discontinued) Sudden Infant Death Syndrome: Implications of Altered Physiological Control During Sleep
Current Pediatric Reviews Subclinical Hypothyroidism in Patients with Diabetic Retinopathy: Role of Vascular Endothelial Growth Factor
Endocrine, Metabolic & Immune Disorders - Drug Targets Editorial [Hot Topic: The Evolution of Cell Therapy Towards Enhancing Vascular Regeneration in the Clinic (Guest Editors: Drew Kuraitis and Erik J. Suuronen)]
Current Vascular Pharmacology Nothing But Stress – The Interplay of Angiotensin II, Inflammation, Hypertension and Atherosclerosis: Implications for Atherosclerotic Plaque Stability
Vascular Disease Prevention (Discontinued) Resurgence of Herbal Antihypertensives in Management of Hypertension
Current Hypertension Reviews Functional Non-Synonymous Polymorphisms Prediction Methods: Current Approaches and Future Developments
Current Medicinal Chemistry Prognostic Role of Sub-Clinical Hypothyroidism in Chronic Heart Failure Outpatients
Current Pharmaceutical Design Smoking and Atherosclerosis: Mechanisms of Disease and New Therapeutic Approaches
Current Medicinal Chemistry Molecular Mechanisms of Inflammation. Anti-Inflammatory Benefits of Virgin Olive Oil and the Phenolic Compound Oleocanthal
Current Pharmaceutical Design Atherosclerotic Plaque Stabilization - Potential Role for Immunomodulatory Therapy
Vascular Disease Prevention (Discontinued) Antioxidant Effect of a Nitrated Cyclic Nucleotide Functioning as an Endogenous Electrophile
Current Topics in Medicinal Chemistry A Critical and Comprehensive Insight on Heme Oxygenase and Related Products Including Carbon Monoxide, Bilirubin, Biliverdin and Ferritin in Type-1 and Type-2 Diabetes
Current Pharmaceutical Design BMPS and Liver: More Questions than Answers
Current Pharmaceutical Design Exploring Old Drugs for the Treatment of Hematological Malignancies
Current Medicinal Chemistry Endothelial Function in Renal Transplant Recipients is Associated with Circulating Nitric Oxide, ACE Inhibitor Use and Time After Transplantation
Vascular Disease Prevention (Discontinued)