Abstract
The deregulated proteolysis is associated with various diseases in humans. Proteases are commonly regarded as the therapeutic targets. Almost one-third of all proteolytic enzymes in humans are serine proteases. This work provides a brief characteristic of the proteinaceous natural inhibitors, mostly of serine proteases. The examples of some classical and recently identified canonical and noncanonical inhibitors as well as serpins are described. Their actual and potential therapeutic applications are discussed.
Keywords: Serine proteases, canonical, non-canonical inhibitors, serpins.
Current Pharmaceutical Design
Title:Natural Proteinaceous Inhibitors of Serine Proteases
Volume: 19 Issue: 6
Author(s): Dawid Debowski
Affiliation:
Keywords: Serine proteases, canonical, non-canonical inhibitors, serpins.
Abstract: The deregulated proteolysis is associated with various diseases in humans. Proteases are commonly regarded as the therapeutic targets. Almost one-third of all proteolytic enzymes in humans are serine proteases. This work provides a brief characteristic of the proteinaceous natural inhibitors, mostly of serine proteases. The examples of some classical and recently identified canonical and noncanonical inhibitors as well as serpins are described. Their actual and potential therapeutic applications are discussed.
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Cite this article as:
Debowski Dawid, Natural Proteinaceous Inhibitors of Serine Proteases, Current Pharmaceutical Design 2013; 19 (6) . https://dx.doi.org/10.2174/138161281906140714121225
DOI https://dx.doi.org/10.2174/138161281906140714121225 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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