Abstract
A growing array of synthetic bone regeneration scaffolds has been in use over the last century. These scaffolds aim to provide a three dimensional substrate for bone cells to populate on and to function appropriately.
The majority of commercially-available scaffolds are based on calcium sulphate salts, calcium phosphate salts, or composites of the two. The mechanical and biological properties of these scaffolds are a result of the properties of the constituent materials and their ratio in the composite.
This review addresses the mechanical and biological characteristics and provides an up-to-date summary of the clinical data available about the use of these calcium-based scaffolds. It will also assess the benefit of using stem cell technology along with this type of scaffolds. This article links between the basic science evidence and the clinical outcomes and details the commercially-available options.
Keywords: Bone healing, bone regeneration, calcium phosphate, calcium sulphate, scaffold, stem cell therapy, bone cells, bone scaffolds, bone auto-grafts.
Current Stem Cell Research & Therapy
Title:Calcium Salts Bone Regeneration Scaffolds: A Review Article
Volume: 7 Issue: 5
Author(s): Salah Hammouche, Wasim Khan, Harriet Drouin, Henry Procter and Michael McNicholas
Affiliation:
Keywords: Bone healing, bone regeneration, calcium phosphate, calcium sulphate, scaffold, stem cell therapy, bone cells, bone scaffolds, bone auto-grafts.
Abstract: A growing array of synthetic bone regeneration scaffolds has been in use over the last century. These scaffolds aim to provide a three dimensional substrate for bone cells to populate on and to function appropriately.
The majority of commercially-available scaffolds are based on calcium sulphate salts, calcium phosphate salts, or composites of the two. The mechanical and biological properties of these scaffolds are a result of the properties of the constituent materials and their ratio in the composite.
This review addresses the mechanical and biological characteristics and provides an up-to-date summary of the clinical data available about the use of these calcium-based scaffolds. It will also assess the benefit of using stem cell technology along with this type of scaffolds. This article links between the basic science evidence and the clinical outcomes and details the commercially-available options.
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Cite this article as:
Hammouche Salah, Khan Wasim, Drouin Harriet, Procter Henry and McNicholas Michael, Calcium Salts Bone Regeneration Scaffolds: A Review Article, Current Stem Cell Research & Therapy 2012; 7 (5) . https://dx.doi.org/10.2174/157488812802481436
DOI https://dx.doi.org/10.2174/157488812802481436 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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