Abstract
A growing array of synthetic bone regeneration scaffolds has been in use over the last century. These scaffolds aim to provide a three dimensional substrate for bone cells to populate on and to function appropriately.
The majority of commercially-available scaffolds are based on calcium sulphate salts, calcium phosphate salts, or composites of the two. The mechanical and biological properties of these scaffolds are a result of the properties of the constituent materials and their ratio in the composite.
This review addresses the mechanical and biological characteristics and provides an up-to-date summary of the clinical data available about the use of these calcium-based scaffolds. It will also assess the benefit of using stem cell technology along with this type of scaffolds. This article links between the basic science evidence and the clinical outcomes and details the commercially-available options.
Keywords: Bone healing, bone regeneration, calcium phosphate, calcium sulphate, scaffold, stem cell therapy, bone cells, bone scaffolds, bone auto-grafts.
Current Stem Cell Research & Therapy
Title:Calcium Salts Bone Regeneration Scaffolds: A Review Article
Volume: 7 Issue: 5
Author(s): Salah Hammouche, Wasim Khan, Harriet Drouin, Henry Procter and Michael McNicholas
Affiliation:
Keywords: Bone healing, bone regeneration, calcium phosphate, calcium sulphate, scaffold, stem cell therapy, bone cells, bone scaffolds, bone auto-grafts.
Abstract: A growing array of synthetic bone regeneration scaffolds has been in use over the last century. These scaffolds aim to provide a three dimensional substrate for bone cells to populate on and to function appropriately.
The majority of commercially-available scaffolds are based on calcium sulphate salts, calcium phosphate salts, or composites of the two. The mechanical and biological properties of these scaffolds are a result of the properties of the constituent materials and their ratio in the composite.
This review addresses the mechanical and biological characteristics and provides an up-to-date summary of the clinical data available about the use of these calcium-based scaffolds. It will also assess the benefit of using stem cell technology along with this type of scaffolds. This article links between the basic science evidence and the clinical outcomes and details the commercially-available options.
Export Options
About this article
Cite this article as:
Hammouche Salah, Khan Wasim, Drouin Harriet, Procter Henry and McNicholas Michael, Calcium Salts Bone Regeneration Scaffolds: A Review Article, Current Stem Cell Research & Therapy 2012; 7 (5) . https://dx.doi.org/10.2174/157488812802481436
DOI https://dx.doi.org/10.2174/157488812802481436 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Role of Traditional Chinese Herbal Medicines and Bioactive Ingredients on Ion Channels: A Brief Review and Prospect
CNS & Neurological Disorders - Drug Targets Editorial (Hot Topic: Advances in Dystonia)
Current Neuropharmacology Chaperone-like Activity of alpha-Crystallin and Other Small Heat Shock Proteins
Current Protein & Peptide Science Fruit as Potent Natural Antioxidants and Their Biological Effects
Current Pharmaceutical Biotechnology Dopaminergic Modulation of Cognitive Control: Distinct Roles for the Prefrontal Cortex and the Basal Ganglia
Current Pharmaceutical Design Recent Progress in Metal-Mediated Trifluoroethylation
Current Organic Chemistry Serotonin and Human Cognitive Performance
Current Pharmaceutical Design Human Mesenchymal Stem Cells (hMSCs) as Targets of DNA Damaging Agents in Cancer Therapy
Current Cancer Drug Targets Follow-Up Study of Olfactory Deficits, Cognitive Functions, and Volume Loss of Medial Temporal Lobe Structures in Patients with Mild Cognitive Impairment
Current Alzheimer Research Chiral Kinase Inhibitors
Current Topics in Medicinal Chemistry Eriocalyxin B-Induced Apoptosis in Pancreatic Adenocarcinoma Cells Through Thiol-Containing Antioxidant Systems and Downstream Signalling Pathways
Current Molecular Medicine Control and Role of Plateau Potential Properties in the Spinal Cord
Current Pharmaceutical Design Protein Conformational Misfolding and Amyloid Formation: Characteristics of a New Class of Disorders that Include Alzheimers and Prion Diseases
Current Medicinal Chemistry DNA Methylation Markers in Lung Cancer
Current Genomics Antipsychotic Medication: The Potential Role of 5-HT1A Receptor Agonism
Current Pharmaceutical Design Small Molecule Natural Products and Alzheimer’s Disease
Current Topics in Medicinal Chemistry Editorial: Current Strategies for Drug Discovery Targeting Neurological Autoimmune Diseases
Central Nervous System Agents in Medicinal Chemistry The Interaction of Zinc Oxide/Green Tea Extract Complex Nanoparticles and its Effect on Monosodium Glutamate Toxicity in Liver of Rats
Current Pharmaceutical Biotechnology Molecular Methods for Individualization of Psychotropic Drug Treatment
Current Pharmacogenomics The Effects of Mindfulness-Based Interventions on Sleep Disturbance: A Meta-Analysis
Adolescent Psychiatry