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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid

Author(s): Adriano Mollica, Roberto Costante, Azzurra Stefanucci and Ettore Novellino

Volume 22 , Issue 8 , 2015

Page: [696 - 711] Pages: 16

DOI: 10.2174/0929866522666150206170716

Price: $65


Mono or di-substituted prolines, namely proline chimeras of natural or synthetic origin, carry the side chain of other specific amino acids on the pyrrolidine ring. Thus, proline chimeras are useful tools for a wide range of chemical and biological applications as chiral synthons or building blocks for peptidomimetic design. We focused our attention on domoic acid and kainic acid and we report here a concise and up to date review on their stereoselective and asymmetric syntheses.

Keywords: Asymmetric synthesis, building blocks, domoic acid, kainic acid, proline chimeras.

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