Abstract
Bax inhibitor-1 (BI-1) is an evolutionarily-conserved endoplasmic reticulum protein. The expression of BI-1 in mammalian cells suppresses apoptosis induced by Bax, a pro-apoptotic member of the Bcl-2 family. BI-1 has been shown to be associated with calcium (Ca2+) levels, reactive oxygen species (ROS) production, cytosolic acidification, and autophagy as well as endoplasmic reticulum stress signaling pathways. According to both in vitro and clinical studies, BI-1 promotes the characteristics of cancers. In other diseases, BI-1 has also been shown to regulate insulin resistance, adipocyte differentiation, hepatic dysfunction and depression. However, the roles of BI-1 in these disease conditions are not fully consistent among studies. Until now, the molecular mechanisms of BI-1 have not directly explained with regard to how these conditions can be regulated. Therefore, this review investigates the physiological role of BI-1 through molecular mechanism studies and its application in various diseases.
Keywords: Bax inhibitor-1, ER stress, lysosome, reactive oxygen species, unfolded protein response.
Related Books
Oxygen, the Breath of Life: Boon and Bane in Human Health, Disease, and Therapy
Evaluation of Cellular Processes by In Vitro Assays
Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies
GPI Membrane Anchors – The Much Needed link
MCQs Series for Life Sciences
MCQs Series for Life Sciences
Sialobiology: Structure, Biosynthesis and Function. Sialic Acid Glycoconjugates in Health and Disease
Synthesis and Biological Applications of Glycoconjugates
The Art and Science of Poisons
Sex Steroids and Apoptosis In Skeletal Muscle: Molecular Mechanisms
81