Abstract
Both Alzheimers disease type pathology (neuritic plaques and neurofibrillary tangles) and evidence of atherosclerosis and infarcts are common in autopsy specimens from the brains of patients enrolled in longitudinal prospective cohorts; the relative contribution of each of these to overall cognitive function is unclear. In addition whether each of these two forms of brain pathology can accelerate the appearance of the other is also unclear. In this paper we examine the relationship among Alzheimers brain pathology, cerebral infarcts and cerebral atherosclerosis. We conclude that each is an independent predictor of dementia. Moreover we do not find that atherosclerosis increases Alzheimers type brain pathology or vice versa.
Keywords: Atherosclerosis, infarction, dementia, amyloid, cerebral infarction, Parkinsonian appearing, hypotension, intracranial atherosclerosis, Endothelial damage, cardiovascular risk factors, neurofibrillary tangle score, Abeta deposition
Current Alzheimer Research
Title: Vascular Dementia: Atherosclerosis, Cognition and Alzheimers Disease
Volume: 8 Issue: 4
Author(s): R. J. OBrien
Affiliation:
Keywords: Atherosclerosis, infarction, dementia, amyloid, cerebral infarction, Parkinsonian appearing, hypotension, intracranial atherosclerosis, Endothelial damage, cardiovascular risk factors, neurofibrillary tangle score, Abeta deposition
Abstract: Both Alzheimers disease type pathology (neuritic plaques and neurofibrillary tangles) and evidence of atherosclerosis and infarcts are common in autopsy specimens from the brains of patients enrolled in longitudinal prospective cohorts; the relative contribution of each of these to overall cognitive function is unclear. In addition whether each of these two forms of brain pathology can accelerate the appearance of the other is also unclear. In this paper we examine the relationship among Alzheimers brain pathology, cerebral infarcts and cerebral atherosclerosis. We conclude that each is an independent predictor of dementia. Moreover we do not find that atherosclerosis increases Alzheimers type brain pathology or vice versa.
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Cite this article as:
J. OBrien R., Vascular Dementia: Atherosclerosis, Cognition and Alzheimers Disease, Current Alzheimer Research 2011; 8 (4) . https://dx.doi.org/10.2174/156720511795745267
DOI https://dx.doi.org/10.2174/156720511795745267 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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