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Current Enzyme Inhibition

Editor-in-Chief

ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Discovery of Dual Chemotherapy Drug Candidates Designed by Molecular Hybridization

Author(s): Rodolfo do Couto Maia and Carlos Alberto Manssour Fraga

Volume 6, Issue 4, 2010

Page: [171 - 182] Pages: 12

DOI: 10.2174/157340810794578515

Price: $65

Abstract

Molecular hybridization approach is a powerful medicinal chemistry tool for designing ligands and prototypes able to act in at least two different molecular targets, promoting a beneficial effect to the treatment of multifactorial diseases. In this context, this review describes some examples where the use of this molecular modification approach lead to the design of novel chemotherapy prototypes able to act simultaneously in more than one target enzyme useful to control diseases promoted by bacterial, viral, protozal or fungal pathogens.

Keywords: Molecular hybridization, chemotherapy, drug resistance, chemotherapeutic agents, hybrid therapy, biomacromolecule, drug-drug interactions, HYBRID ANTIBACTERIAL PROTOTYPES, aminoglycosides, enzymatic modification, antibiotics


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