Abstract
Molecular hybridization approach is a powerful medicinal chemistry tool for designing ligands and prototypes able to act in at least two different molecular targets, promoting a beneficial effect to the treatment of multifactorial diseases. In this context, this review describes some examples where the use of this molecular modification approach lead to the design of novel chemotherapy prototypes able to act simultaneously in more than one target enzyme useful to control diseases promoted by bacterial, viral, protozal or fungal pathogens.
Keywords: Molecular hybridization, chemotherapy, drug resistance, chemotherapeutic agents, hybrid therapy, biomacromolecule, drug-drug interactions, HYBRID ANTIBACTERIAL PROTOTYPES, aminoglycosides, enzymatic modification, antibiotics
Current Enzyme Inhibition
Title: Discovery of Dual Chemotherapy Drug Candidates Designed by Molecular Hybridization
Volume: 6 Issue: 4
Author(s): Rodolfo do Couto Maia and Carlos Alberto Manssour Fraga
Affiliation:
Keywords: Molecular hybridization, chemotherapy, drug resistance, chemotherapeutic agents, hybrid therapy, biomacromolecule, drug-drug interactions, HYBRID ANTIBACTERIAL PROTOTYPES, aminoglycosides, enzymatic modification, antibiotics
Abstract: Molecular hybridization approach is a powerful medicinal chemistry tool for designing ligands and prototypes able to act in at least two different molecular targets, promoting a beneficial effect to the treatment of multifactorial diseases. In this context, this review describes some examples where the use of this molecular modification approach lead to the design of novel chemotherapy prototypes able to act simultaneously in more than one target enzyme useful to control diseases promoted by bacterial, viral, protozal or fungal pathogens.
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Cite this article as:
do Couto Maia Rodolfo and Alberto Manssour Fraga Carlos, Discovery of Dual Chemotherapy Drug Candidates Designed by Molecular Hybridization, Current Enzyme Inhibition 2010; 6 (4) . https://dx.doi.org/10.2174/157340810794578515
DOI https://dx.doi.org/10.2174/157340810794578515 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
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