Abstract
B cells are once again gaining prominence as important programmers of CD4 T cell responses. With widespread use of B cell depletion therapy in the clinic, proving effective in treating diseases previously considered T cellmediated, the time is right for a re-appraisal of the B cell. Though typically considered weak, Th2 driving APC, it is now clear that they are necessary for a robust and long-lived CD4 T cell response in many settings. The sphere of B cell influence extends well beyond that of simply antibody production; antigen presentation, cytokine secretion, costimulation and development of lymphoid tissue architecture are all critical aspects of B cell immunobiology, the absence of which has serious impacts for T cell priming and memory. The aim of this review is to look at non-antibody mediated B cell function and to ask how, where and when do B cells influence the CD4 T cell response?
Keywords: B cell, T cell, antigen presentation, TLR, memory, cell responses, antibody production, B cell immunobiology, CD4 T cell response, dendritic cells, protein antigens, gross abnormalities, memory cells, lymphoid organogenesis, amateur
Infectious Disorders - Drug Targets
Title:B Cells: Programmers of CD4 T Cell Responses
Volume: 12 Issue: 3
Author(s): Tom A. Barr, Mohini Gray and David Gray
Affiliation:
Keywords: B cell, T cell, antigen presentation, TLR, memory, cell responses, antibody production, B cell immunobiology, CD4 T cell response, dendritic cells, protein antigens, gross abnormalities, memory cells, lymphoid organogenesis, amateur
Abstract: B cells are once again gaining prominence as important programmers of CD4 T cell responses. With widespread use of B cell depletion therapy in the clinic, proving effective in treating diseases previously considered T cellmediated, the time is right for a re-appraisal of the B cell. Though typically considered weak, Th2 driving APC, it is now clear that they are necessary for a robust and long-lived CD4 T cell response in many settings. The sphere of B cell influence extends well beyond that of simply antibody production; antigen presentation, cytokine secretion, costimulation and development of lymphoid tissue architecture are all critical aspects of B cell immunobiology, the absence of which has serious impacts for T cell priming and memory. The aim of this review is to look at non-antibody mediated B cell function and to ask how, where and when do B cells influence the CD4 T cell response?
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Cite this article as:
A. Barr Tom, Gray Mohini and Gray David, B Cells: Programmers of CD4 T Cell Responses, Infectious Disorders - Drug Targets 2012; 12 (3) . https://dx.doi.org/10.2174/187152612800564446
DOI https://dx.doi.org/10.2174/187152612800564446 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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