Identification of a Novel Glutathione Conjugate of Diclofenac by LTQOrbitrap

Author(s): Yohannes Teffera, Daniel J. Waldon, Adria E. Colletti, Brian K. Albrecht, Zhiyang Zhao.

Journal Name: Drug Metabolism Letters

Volume 2 , Issue 1 , 2008

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High resolution accurate MS with an LTQ-Orbitrap identified two novel metabolites of diclofenac in rat bile and rat and human hepatocyte incubations: a benzyl-S-glutathione conjugate and 2-(2,6-dichlorophenylamino) benzoic acid. A mechanism for the bioactivation of diclofenac involving decarboxylation is proposed.

Keywords: glutathione adduct, DPABA, diclofenac decarboxylation, Bioactivation pathway, Reconstructed ion chromatogram

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Article Details

Year: 2008
Page: [35 - 40]
Pages: 6
DOI: 10.2174/187231208783478506

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