Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Gemini Surfactants: A New Family of Building Blocks for Non-Viral Gene Delivery Systems

Author(s): Shawn D. Wettig, Ronald E. Verrall, Marianna Foldvari.

Abstract:

Gemini surfactants provide a significant opportunity in the development of new non-viral delivery systems designed for gene therapy applications. This review summarizes the wide range of gemini surfactant structures that have been employed for DNA transfection in vitro. A general observation is that those structures capable of inducing a wide variety of polymorphic structures (lamellar, hexagonal, or cubic phases) demonstrate higher transfection efficiencies. Those compounds whose structures result in pH-dependent changes in aggregate structure similarly show higher levels of transfection. In vivo transfection using gemini surfactants has been demonstrated in only three cases, and in a recent study the transfection was linked to a specific therapeutic response.

Keywords: Gene therapy, gemini surfactant, non-viral, transfection, delivery system, in vivo, in vitro

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2008
Page: [9 - 23]
Pages: 15
DOI: 10.2174/156652308783688491