IL-17 as a Potential Target for Modulating Airway Neutrophilia

Author(s): Martti Laan , Anders Linden .

Journal Name: Current Pharmaceutical Design

Volume 8 , Issue 20 , 2002

Abstract:

Several chronic inflammatory airway diseases are characterized by an increased number of neutrophils in the airways. There is evidence that the recruitment of these neutrophils can be controlled by certain T-lymphocytes. However, the mechanisms behind this T-cell control of airway neutrophilia are poorly understood. In this review, we summarize the evidence that interleukin (IL)-17 released from T-lymphocytes of the CD45RO+ subset can link the activation of these T-cells to the recruitment and activation of neutrophils. This evidence suggests that pharmacotherapeutical modulation of neutrophilic airway inflammation can be achieved using several different strategies, including inhibition of IL-17 production by cAMP elevating agents or certain nuclear factor inhibitors, neutralization of released IL-17 protein by specific anti-IL-17-antibodies, blockade of the IL-17 receptor as well as inhibition of certain MAP kinases mediating the post receptor effects of IL-17 in airway cells. Additional studies on animals in vivo and patients, respectively, are needed to further evaluate the pharmacotherapeutical potential of these strategies.

Keywords: potential target, neutrophilia, epithelial damage, cytokine receptor, kidney carcinoma epithelial cells, airway neutrophils

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Article Details

VOLUME: 8
ISSUE: 20
Year: 2002
Page: [1855 - 1861]
Pages: 7
DOI: 10.2174/1381612023393864
Price: $58

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