Dendritic Cell Endothelium Interaction in Autoimmunity

Author(s): C. L. Schlichting, W. D. Schareck, M. Weis.

Journal Name: Current Pharmaceutical Design

Volume 10 , Issue 2 , 2004

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Abstract:

Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.

Keywords: autoimmunity, dendritic cells, endothelium, endothelial cell, migration, inflammation

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2004
Page: [171 - 181]
Pages: 11
DOI: 10.2174/1381612043453397
Price: $58

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